Version 2.77

Term Description

Nottingham histologic grade (NHG) is a prognostic indicator for patients with breast carcinoma. The NHG is based on a combination of individual scores for the degree of tubule formation [LOINC: 85321-8], nuclear pleomorphism [LOINC: 44645-0], and mitotic activity [LOINC: 85300-2]. Each parameter is given a score from 1 to 3, and the final NGH grade is determined based on the sum of those three scores. Grade 1 is assigned for a summed score of 3, 4 or 5; grade 2 is assigned for a summed score of 6 or 7; and grade 3 is assigned for a summed score of 8 or 9. A higher grade is associated with a more aggressive cancer, and patients with grade 3 carcinoma tend to have lower long-term survival rates compared to patients with grade 1. The individual tubule formation and mitotic activity scores may also be independent predictors of survival. PMID: 11865000
Source: Regenstrief LOINC

Fully-Specified Name

Component
Histologic grade
Property
Score
Time
Pt
System
Breast cancer specimen
Scale
SemiQn
Method
Nottingham

Additional Names

Short Name
Histo grade Score Br ca spec Nottingham
Display Name
Histologic grade Nottingham (Breast cancer specimen) [Score]
Consumer Name Alpha Get Info
Histologic grade, Breast cancer specimen

Normative Answer List: LL4561-8

Source: College of American Pathologists
Answer Code Score Answer ID
Nottingham grade 1

Scores of 3, 4 or 5

 LA27823-6
Nottingham grade 2

Scores of 6 or 7

 LA27824-4
Nottingham grade 3

Scores of 8 or 9

 LA27825-1
Only microinvasion present (not graded) LA27219-7
No residual invasive carcinoma after presurgical (neoadjuvant) therapy LA27220-5
Score cannot be determined LA27221-3

Basic Attributes

Class
PATH.HISTO
Type
Laboratory
First Released
Version 2.17
Last Updated
Version 2.75
Change Reason
Removed CAP Copyright and Method because this concept is not specific to CAP, moved Nottingham from Component to Method, changed System from "Breast tumor" because the concept is specific to breast cancer, added answer list
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
85904-1 Cancer pathology panel - Breast cancer specimen by CAP cancer protocols

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Grado histológico:Puntuación:Punto temporal:Muestra de cancer de mama:Semicuantitativo:Nottingham
Synonyms: Histologia Semicuantitativo
es-MX Spanish (Mexico) Grado histológico:Puntaje:Punto temporal:Muestra de cáncer de mama:Ordinal:Nottingham
it-IT Italian (Italy) Grado istologico:Punteggio:Pt:Tumore della mammella, campione:SemiQn:Nottingham
Synonyms: Campione di tumore Campione di tumore della mammella Istologia Neoplasia maligna Patologia Petto Punto nel tempo (episodio)
zh-CN Chinese (China) 组织学分级:评分:时间点:乳腺癌标本:半定量型:诺丁汉法
Synonyms: Nottingham 法 乳房 乳腺癌（乳癌）标本（样本、样品、试样） 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 分值;得分;分数 受检物 时刻;随机;随意;瞬间 样品 样本 癌 癌（癌症、癌变）标本（样本、样品、试样） 级;品级;成绩;评分;级别;等;等级;年级;分级 组织学 组织学（组织）分级（等级、级别）;组织分级;組織分級 试样

Example Units

Unit Source
{score} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=44648-4