83053-9
Cells.programmed cell death ligand 1/100 viable tumor cells in Tissue by Immune stain
Active
Part Description
LP221212-6 Cells.programmed cell death ligand 1
Programmed cell death-ligand 1 (PD-L1), also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is a protein that in humans is encoded by the CD274 gene. PD-L1 is the major ligand for the programmed cell death-1 (PD-1) receptor, which is present on the surface of T, B and NK cells and is part of the B7-CD28 superfamily. Binding PD-L1 and PD-L2 to the PD-1 receptor found on T-cells inhibits T cell proliferation and cytokine production. An increase PD-L1 expression occurs in some tumors, which helps protect them against active T-cell immune surveillance by binding to PD-1 and inhibiting the T-cell response. Positive PD-L1 immunohistochemistry in tumor cells may predict tumor response to therapy with immune checkpoint inhibitors, which are a new class of drugs that trigger an immune response against cancer cells by effectively suppressing the tumor's ability to inhibit the immune response. PMID: 25682184 Drugs in this class include pembrolizumab and nivolumab, both of which are anti-PD-1 receptor antibodies, and atezolizumab, which is an anti-PD-L1 antibody. PD-L1 may be a prognostic, diagnostic, and therapeutic marker in a variety of neoplasms, including carcinomas of the bladder, lung, and kidney.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Cells.programmed cell death ligand 1/100 viable tumor cells
- Property
- NFr
- Time
- Pt
- System
- Tiss
- Scale
- Qn
- Method
- Immune stain
Additional Names
- Short Name
- Cells.PD-L1/100 viab tum NFr Tiss ImStn
- Display Name
- Cells.programmed cell death ligand 1/100 viable tumor cells Immune stain (Tiss)
- Consumer Name Alpha Get Info
- Cells.programmed cell death ligand 1 per 100 Viable Tumor Cells, Tissue
Basic Attributes
- Class
- PATH
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.73
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 16229
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Células. Muerte celular programada del ligando 1/100 células tumorales viables: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Células ligando de muerte celular programada 1/100 células tumorales viables: |
| it-IT | Italian (Italy) | Cellule.ligando 1 di morte cellulare programmata/100 cellule tumorali vitali: Synonyms: Frazione numerica Patologia PD-L1 Punto nel tempo (episodio) Tessuto & |
| nl-NL | Dutch (Netherlands) | cellen.geprogrammeerde celdood ligand 1/100 levensvatbare tumorcellen: |
| pl-PL | Polish (Poland) | Komórki.ligand 1 programowanej śmierci komórki/100 żywych komórek nowotworowych: Synonyms: barwnik immunologiczny Ligand 1 programowanej śmierci komórki/100 żywych komórek nowotworowych Ligand receptora programowanej śmierci 1 |
| zh-CN | Chinese (China) | 细胞.程序性死亡配体 1/100 个活肿瘤细胞: Synonyms: 100 个活（活的、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=83053-9
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright