Version 2.78

Term Description

This term is to test for the presence of a mutation within all coding regions of the following genes: H3-3A, H3-3B, H3C2, H3C3 and HIST2H3C. This test does not differenctiate between somatic and germline alterations.
Source: Regenstrief LOINC

Part Description

LP438338-8   H3 Clustered Histone 14 gene
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015] Source: National Library of Medicine,

Fully-Specified Name

Component
H3 Clustered Histone 14 gene targeted mutation analysis
Property
Find
Time
Pt
System
Tiss
Scale
Doc
Method
Molgen

Additional Names

Short Name
H3C14 gene Mut Anl Tiss
Display Name
H3C14 gene targeted mutation analysis Molgen Doc (Tiss)
Consumer Name Alpha Get Info
H3C14 gene targeted mutation analysis, Tissue

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.78
Last Updated
Version 2.78
Order vs. Observation
Order

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