Version 2.76

Term Description

Method can be DIRECT SPECTOPHOTOMETRY, WET CHEMISTRY or DRY SLIDE (TBIL)
Source: Regenstrief LOINC

Part Description

LP15448-1   Bilirubin
Bilirubin is an orange-yellow pigment produced by the normal breakdown of heme, a component of the hemoglobin found in red blood cells. It is processed by the liver and excreted in bile. Conditions that cause red blood cell breakdown or interfere with liver or bile processing can cause elevated levels of bilirubin. Bilirubin exists in many forms. Non-glucuronidated bilirubin (also called unconjugated or indirect) is the breakdown product of heme and is not water-soluble. Hemolytic anemias, which cause increased red blood cell breakdown, are one cause of elevated non-glucuronidated bilirubin. Glucuronidated bilirubin (also called conjugated) is a water-soluble form of bilirubin that is made in the liver by the addition of sugar molecules to non-glucuronidated bilirubin. Conditions that affect liver function (such as hepatitis, cirrhosis and liver tumors) or physically block the bile ducts (such as gallstones) can cause elevated levels of glucuronidated bilirubin. A third form of bilirubin is that which is bound to albumin, and it is also known as delta bilirubin because it was originally identified based on the unexpected difference between the total bilirubin level and the level of glucuronidated plus non-glucuronidated bilirubin in some patient samples. Prior to the discovery of albumin-bound bilirubin, the term "direct" bilirubin was used as a synonym for glucuronidated bilirubin, but direct bilirubin is actually glucuronidated plus delta bilirubin (bilirubin covalently bound to albumin). Source: Regenstrief LOINC

Reference Information

Type Source Reference
Mapping Guidance Regenstrief Help Total bilirubin = direct + indirect Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations
Webcontent Lab Tests Online®Copyright Copyright © 2021 Lab Tests Online. All rights reserved. Bilirubin

Fully-Specified Name

Component
Bilirubin
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Bilirub SerPl-mCnc
Display Name
Bilirubin [Mass/Vol]
Consumer Name Alpha Get Info
Bilirubin, Blood

Associated Observations

95405-7 Assay related variables panel [PhenX]

This panel contains a collection of ask-at-order entry questions and associated observations that may be included within various PhenX protocols for biomarker testing. Each protocol varies as to the items asked & recorded, so not all terms will be used but are displayed together for users to find the appropriate LOINCs.

LOINC Name R/O/C Cardinality Example UCUM Units
95405-7 Assay related variables panel
Indent30525-0 Age a
Indent46098-0 Sex
Indent66165-2 Last ate or drank anything other than plain water [Date and time]
Indent80331-2 Date and time of last void {clock_time}
Indent66177-7 Do you have hemophilia?
Indent94741-6 Cancer chemotherapy received in the past 4W
Indent66178-5 Have you received cancer chemotherapy in the past four weeks or do you anticipate such therapy in the next four weeks?
Indent66504-2 Exclusion Criteria
Indent41395-5 Collection date of Urine
Indent74751-9 Collection time of Urine {clock_time}
Indent94331-6 Specimen Collection procedure comment
Indent95044-4 Patient refused specimen collection
Indent94846-3 History of Specimen collection problem
Indent94847-1 Reason specimen not collected
Indent77301-0 Reason care action performed or not
Indent66180-1 Was blood drawn?
Indent66181-9 Was full sample obtained?
Indent94330-8 Specimen Processing comment
Indent8251-1 Service comment
Indent85069-3 Lab test method [Type]
Indent66200-7 Repeatability of the assay {ratio}
Indent66201-5 Coefficient of variation for the assay {CV}
Indent66208-0 Make of the equipment used to perform...
Indent74719-6 Manufacturer of the equipment used
Indent74720-4 Device name

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 1.0
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
22

Member of these Panels

LOINC Long Common Name
34543-9 Bilirubin direct and total panel [Mass/volume] - Serum or Plasma
98153-0 Child-Pugh panel
24322-0 Comprehensive metabolic 1998 panel - Serum or Plasma
24323-8 Comprehensive metabolic 2000 panel - Serum or Plasma
24324-6 Hepatic function 1996 panel - Serum or Plasma
24325-3 Hepatic function 2000 panel - Serum or Plasma
48796-7 Hepatitis C virus FibroSURE panel - Serum or Plasma
78698-8 Liver fibrosis score panel - Serum or Plasma Calculated by HepaScore
54232-4 Metabolic panel.large animal - Serum or Plasma
54233-2 Metabolic panel.small animal - Serum or Plasma
93691-4 Nonalcoholic steatohepatitis and fibrosis panel - Serum or Plasma
96789-3 Sequential Organ Failure Assessment SOFA

Member of these Groups Get Info

LOINC Group Group Name
LG6199-6 Bilirubin|MCnc|Pt|ANYBldSerPl
LG49848-1 Bilirubin|Pt|Ser/Plas|584.673 g/mole

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Bilirubin
de-DE German (Germany) Bilirubin:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
el-GR Greek (Greece) Χολερυθρίνη:Συγκέντρωση μάζας:Χρονική στιγμή:Ορός/Πλάσμα:Ποσοτική:
es-MX Spanish (Mexico) Bilirrubina:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
es-AR Spanish (Argentina) bilirrubina:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-ES Spanish (Spain) Bilirrubina:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
et-EE Estonian (Estonia) Bilirubiin:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Bilirubine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-BE French (Belgium) Bilirubine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Bilirubine:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
it-IT Italian (Italy) Bilirubina:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Concentrazione di Massa Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 빌리루빈:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) bilirubine:massa/volume:moment:serum of plasma:kwantitatief:
pl-PL Polish (Poland) Bilirubina:stężenie masowe:punkt w czasie:surowica lub osocze:ilościowy:
pt-BR Portuguese (Brazil) Bilirrubina:MCnc:Pt:Sor/Plas:Qn:
Synonyms: ; Bilirub; Bili; TBIL; Bilirubins; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Chemistry
ru-RU Russian (Russian Federation) Билирубин:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Bilirubin:KütlKons:Zmlı:Ser/Plaz:Kant:
uk-UA Ukrainian (Ukraine) Білірубін:Масова Концентрація:МоментЧасу:Сироватка/Плазма:Кількісно:
Synonyms: Bili; Bilirubins; Billirubin; Chemistry; Hematology; Heme; Hepatology; Level; Liver; Mass Concentration; Pl; Plasma; Plsm; Point in time; QNT; Quan; Quant; Quantitative; Random; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR; TBIL; UniversalLabOrders
zh-CN Chinese (China) 胆红素:质量浓度:时间点:血清/血浆:定量型:
Synonyms: TBIL;总胆红素;胆红质 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 血清或血浆

Example Units

Unit Source
mg/dL Example UCUM Units
mg/dL REGENSTRIEF

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=1975-2