LOINC
Version 2.73

30176-2La Crosse virus neutralizing antibody [Presence] in Specimen by Neutralization testActive

Term Description

California encephalitis virus has more than 20 strains, most of which include "strain" in the name. In some cases such as La Crosse virus, however, the name does not signal that it is a strain of California encephalitis.
Source: Regenstrief LOINC

Part Descriptions

LP14236-1   La Crosse virus
La Crosse virus is a mosquito-borne virus causing encephalitis in the United States at higher rates than bacterial meningitis. The disease is recurrent during warm seasons in the Mid-West and mid-Atlantic whose hardwood trees provide breeding sites for the mosquito species Aedes triseriatus. Testing for La Crosse virus should be perfomed on young patients with symptoms of encephalitis in these two parts of the United States during the summer and fall. [PMID:9494831] Source: Regenstrief LOINC

LP14236-1   La Crosse virus
La Crosse encephalitis is an encephalitis caused by an arbovirus (the La Crosse virus) which has a mosquito vector (Ochlerotatus triseriatus synonym Aedes triseriatus).

Historically, most cases of LAC encephalitis occur in the upper Midwestern states (Minnesota, Wisconsin, Iowa, Illinois, Indiana, and Ohio). Recently, more cases are being reported from states in the mid-Atlantic (West Virginia, Virginia and North Carolina) and southeastern (Alabama and Mississippi) regions of the country. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP6416-4   Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. [PMID:32170698] This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. [PMID:169804] Source: Regenstrief LOINC

LP207365-0   Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

Fully-Specified Name

Component
La Crosse virus Ab.Neut
Property
PrThr
Time
Pt
System
XXX
Scale
Ord
Method
Neut

Additional Names

Short Name
LACV NAb Spec Ql Nt
Display Name
La Crosse virus neut ab Neut test Ql (Specimen)
Consumer Name Alpha
La Crosse virus neutralizing antibody, Specimen

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.04
Last Updated
Version 2.72
Change Reason
Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.; Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

zh-CNChinese (China)
拉克罗斯病毒 抗体.中和:存在情况或阈值:时间点:XXX:序数型:中和试验
nl-NLDutch (Netherlands)
La Crosse-virus As.neutraliserend:aanwezigheid:moment:XXX:ordinaal:neutralisatietest
fr-CAFrench (Canada)
Virus La Crosse Ac.neut:Présence-Seuil:Temps ponctuel:XXX:Ordinal:Test de neutralisation
fr-FRFrench (France)
Virus de la Crosse Ac:Présence/Seuil:Ponctuel:Milieux divers:Qualitatif:Neutralisation
it-ITItalian (Italy)
La Crosse, virus Ab.Neut:PrThr:Pt:XXX:Ord:Neut
ko-KRKorean (Korea, Republic of)
러크로스 바이러스 항체:임의농도:검사시점:XXX:순위척도:중화
pt-BRPortuguese (Brazil)
La Crosse vírus Ac:ACnc:Pt:XXX:Ord:Teste de neutralização
es-ARSpanish (Argentina)
[anticuerpo anti - ] virus La Crosse [Ac]:concentración arbitraria:punto en el tiempo:XXX:ordinal:neutralización
es-MXSpanish (Mexico)
LA Crosse virus Ab:Presencia o umbral:Punto temporal:XXX:Ordinal:Prueba de neutralización
es-ESSpanish (Spain)
Virus La Crosse Anticuerpos antineutrófilos:PrThr:Punto temporal:XXX:Ord:Prueba de neutralización

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=30176-2