LOINC
Version 2.67

34487-9Influenza virus A RNA [Presence] in Unspecified specimen by NAA with probe detectionActive

Part Description

LP14239-5   Influenza virus A
Influenza viruses, from the family Orthomyxoviridae, are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C are medically relevant to humans. Aquatic birds harboring avian IAV are the likely natural reservoir for all known IAV subtypes and are probably the original source of all human pandemic IAV strains. IAV maintained in wild birds have been associated with stable host switch events to novel hosts, including most often to domestic poultry but also to horses, swine, toothed whales and humans. The influenza virus life cycle begins with the binding of viral HA to host cell receptors. Endocytosis and HA-mediated fusion of the viral and cellular membranes occurs. Viral ribonucleoprotein complexes are released into the cytoplasm, travel to the nucleus, then are replicated and transcribed by the viral polymerase complex. The new viruses are formed and bud when the newly formed ribonucleicprotein complexes and structural proteins reach the plasma membrane. Further research is needed to better understand how IAVs switch hosts and the viral genetic changes that underlie human adaptation. IAV causes respiratory infections in humans ranging from asymptomatic to fatal. Pandemics are attributed to "novel" viruses which possess a viral hemagglutinin (HA) to which humans do not have immunity. [PMID:20542248 ] [PMID: 25812763]
Influenza viruses A and B are single-stranded RNA enveloped viruses belonging to the Orthomyxoviridae family. The symptoms of infection of Influenza A and B include fever, cough, sore throat, rhinorrhea, nasal congestion, headache, myalgia and malaise. Some patients may experience gastrointestinal symptoms including watery diarrhea, vomiting and abdominal pain. The influenza viruses spread rapidly in enclosed spaces with a documented rate of infection of 70% following a common source of exposure. Infection occurs in the respiratory epithelium in both the upper and lower respiratory tract, and the virus can be found in many specimen types, including nasal aspirates, nasal or nasopharyngeal swabs, throat swabs, sputum and tracheal aspirates. When infection rates reach epidemic proportions, hospitalization of children and elderly patients rises as does the mortality rates of elderly patients.(Manual of Clinical Microbiology, 11th edition, James H. Jorgensen; Karen C. Carroll; Guido Funke; Michael A Pfaller; Marie Louise Landry; Sandra S. Richter; David W. Warnock) Source: Regenstrief LOINC

Fully-Specified Name

Component
Influenza virus A RNA
Property
PrThr
Time
Pt
System
XXX
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
FLUAV RNA XXX Ql NAA+probe
Display Name
FLUAV RNA NAA+probe Ql (Unsp spec)

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.10
Last Updated
Version 2.67
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Member of these Panels

LOINC Long Common Name
55466-7 Influenza virus A H1 2009 pandemic RNA panel - Unspecified specimen by NAA with probe detection
50219-5 Respiratory pathogens DNA and RNA 12a panel - Unspecified specimen by NAA with probe detection
60566-7 Respiratory pathogens DNA and RNA 12b panel - Unspecified specimen by NAA with probe detection
76771-5 Respiratory pathogens RNA 8 panel - Unspecified specimen by NAA with probe detection

Member of these Groups

LG32757-3 Influenza virus

Language Variants Get Info

zh-CNChinese (CHINA)
流感病毒 A 型 RNA:存在情况或阈值:时间点:XXX:序数型:探针法.基因扩增.靶向
nl-NLDutch (NETHERLANDS)
Influenzavirus A RNA:aanwezigheid:moment:XXX:ordinaal:moleculaire techniek (PCR)
fr-BEFrench (BELGIUM)
Virus de l'influenza A ARN:PrThr:Temps ponctuel:XXX:Ordinal:Sonde avec amplification de la cible
fr-CAFrench (CANADA)
Virus de l'influenza A , ARN:Présence-Seuil:Temps ponctuel:XXX:Ordinal:Sonde avec amplification de la cible
fr-FRFrench (FRANCE)
Influenza virus A RNA:PrThr:Pt:XXX:Ord:Probe.amp.tar
de-ATGerman (AUSTRIA)
Influenza A Virus RNA /SM PCR
de-DEGerman (GERMANY)
Influenzavirus A RNA:AKnz:Pkt:XXX:Ord:Probe.amp.tar
it-ITItalian (ITALY)
Influenza A, virus , RNA:PrThr:Pt:XXX:Ord:Sonda.amp.tar
ko-KRKorean (KOREA, REPUBLIC OF)
A형 인플루엔자 바이러스 리보핵산:임의농도:검사시점:XXX:순위척도:DNA 탐색자.증폭.표적
pt-BRPortuguese (BRAZIL)
Influenza vírus A RNA:ACnc:Pt:XXX:Ord:Sonda com limite de detecção da amplificação de alvo
ru-RURussian (RUSSIAN FEDERATION)
Грипп вирус А РНК:PrThr:ТчкВрм:XXX:Пор:Проба.усил.миш
es-ARSpanish (ARGENTINA)
ARN de virus influenza de las aves:concentración arbitraria:punto en el tiempo:XXX:ordinal:sonda.amplificación.blanco
es-ESSpanish (SPAIN)
Virus Influenza A RNA:PrThr:Punto temporal:XXX:Ord:Sonda con amplificación dirigida
tr-TRTurkish (TURKEY)
İnfluenza virüsü A RNA:MevcEşik:Zmlı:XXX:Srl:Prob.amf.hdf

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=34487-9