LOINC
Version 2.71

34589-2von Willebrand factor (vWf) cleaving protease [Presence] in Platelet poor plasmaActive

Part Description

LP32458-9   von Willebrand factor cleaving protease
von Willebrand factor (vWF) cleaving protease, or ADAMTS13, is a metalloprotease that cleaves vWF and thereby limits platelet aggregation and formation of microthrombi. vWF cleaving protease inhibitors can decrease the protease activity and/or more rapidly remove the enzyme from the circulation. Such inhibitors are one cause of thrombotic thrombocytopenic purpura (TTP), a disorder characterized by thrombocytopenia, anemia, fever, and neurologic and renal abnormalities. Idiopathic TTP is often due to anti-ADAMTS13 autoantibodies, while inherited TTP is an autosomal recessive disorder due to mutations in the ADAMTS13 gene that lead to impaired protease function. Work-up of patients with TTP can include vWF cleaving protease activity and, if that activity is low, inhibitor screen followed by quantification. [PMID:18756543] Source: Regenstrief LOINC

Fully-Specified Name

Component
von Willebrand factor cleaving protease
Property
PrThr
Time
Pt
System
PPP
Scale
Ord
Method

Additional Names

Short Name
vWF Cp PPP Ql
Display Name
vWf cleaving protease Ql (PPP)
Consumer Name Alpha
vWf cleaving protease, Blood

Example Answer List LL2354-0

Source: Regenstrief LOINC

Answer Code Score Answer ID
Normal Copyright http://snomed.info/sct ID:17621005 Normal (qualifier value) LA6626-1
Abnormal Copyright http://snomed.info/sct ID:263654008 Abnormal (qualifier value) LA12748-2

Basic Attributes

Class
COAG
Type
Laboratory
First Released
Version 2.10
Last Updated
Version 2.70
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

zh-CNChinese (China)
von Willebrand 因子裂解蛋白酶:存在情况或阈值:时间点:贫血小板血浆:序数型:
nl-NLDutch (Netherlands)
von Willebrand-factor cleaving protease:aanwezigheid:moment:plaatjesarm plasma:ordinaal:
fr-BEFrench (Belgium)
Protéase de clivage du Facteur von Willebrand:PrThr:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:
fr-CAFrench (Canada)
Protéase de coupage Facteur von Willebrand:Présence-Seuil:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:
fr-FRFrench (France)
Facteur Willebrand protéase:Présence/Seuil:Ponctuel:Plasma pauvre en plaquettes:Qualitatif:
it-ITItalian (Italy)
von Willebrand, proteasi di taglio fattore:PrThr:Pt:PPP:Ord:
ko-KRKorean (Korea, Republic of)
폰 빌레브란트 인자 절단 단백분해효소:임의농도:검사시점:혈소판제거혈장:순위척도:
pt-BRPortuguese (Brazil)
fator de von Willebrand clivagem da protease:ACnc:Pt:PPPQ:Ord:
ru-RURussian (Russian Federation)
von Willebrand фактор (vWf) расщепляющая протеаза:PrThr:ТчкВрм:ОПП:Пор:
es-ARSpanish (Argentina)
proteasa desdobladora del factor de von Willebrand:concentración arbitraria:punto en el tiempo:plasma desplaquetado:ordinal:
es-ESSpanish (Spain)
Proteasa divisora del Factor de von Willebrand:PrThr:Punto temporal:Plasma pobre en plaquetas:Ord:
tr-TRTurkish (Turkey)
von Willebrand faktörü parçalıyıcı proteaz:MevcEşik:Zmlı:TFkP:Srl:

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=34589-2