Version 2.77

Term Description

APOE gene allele 1 (34731-0)and 2 (34732-8) identify the allele variant present on the two copies of APOE. The original intent of the APOE gene allele 1, 2, 3 and 4 terms was ambiguous due to confusion between allele numbering (i.e., allele 1 and 2, which represent the two copies of a given gene that are present in single cell) and the APOE allele variants e2, e3 and e4. We have updated the APOE gene allele 1 and 2 terms to match other LOINC allele 1 and 2 terms; we also deprecated the APOE gene allele 3 and 4 terms (34733-6 and 34735-1, respectively) and mapped them to LOINC 21619-2, which should be used to report the APOE genotype.
Source: Regenstrief LOINC

Part Description

LP32795-4   APOE gene allele 2
Apolipoproteins are a family of proteins involved in cholesterol transport and metabolism. Apoliprotein E is important in cholesterol transport throughout the body and is encoded by the APOE gene. The three most common forms of apolipoprotein E are E2, E3 and E4, which are encoded by the APOE allele variants e2, e3 (the wild type form) and e4, respectively. The E3 form is responsible for typical cholesterol metabolism. E2 and E4 are associated with alterations in lipid transport and metabolism, and nearly all patients with type III hyperlipoproteinemia (HLP), a familial disorder associated with early atherosclerosis, exclusively make the E2 form of apolipoprotein E. However, 90% of people that only make E2 have cholesterol levels in the normal range, and only about 10% have type III HLP. E4 may also be a marker for Alzheimer's disease. PMID: 11701639 Source: Regenstrief LOINC, PMID: 11701639

Fully-Specified Name

Component
APOE gene allele 2
Property
ID
Time
Pt
System
Bld/Tiss
Scale
Nom
Method
Molgen

Additional Names

Short Name
APOE allele2 Bld/T
Display Name
APOE gene allele 2 Molgen Nom (Bld/Tiss) [ID]
Consumer Name Alpha Get Info
APOE gene allele 2, Blood or tissue specimen

Example Answer List: LL2984-4

Source: Regenstrief LOINC
Answer Code Score Answer ID
APOE e2 LA21353-0
APOE e3 (wild type) LA21354-8
APOE e4 LA21355-5

Basic Attributes

Class
MOLPATH.MUT
Type
Laboratory
First Released
Version 2.11
Last Updated
Version 2.73
Order vs. Observation
Observation
Common Test Rank Get Info
14960

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) gen APOE alelo 2:presencia o identidad:punto en el tiempo:sangre entera/tejido:Nominal:genética molecular
es-ES Spanish (Spain) Alelo 2 del gen APOE:Código identificador:Punto temporal:Sangre o tejido:Nom:Genética molecular
es-MX Spanish (Mexico) Alelo 2 del gen APOE:Identificador:Punto temporal:Sangre o tejido:Nominal:Genética molecular
fr-FR French (France) APOE gène allèle 2:Identifiant:Ponctuel:Sang/Tissu:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) APOE, allele 2 gene:ID:Pt:Sangue/Tess:Nom:Molgen
Synonyms: Allele 2 gene APOE Gene APOE Genetica molecolare Identificatore Mutazione genica Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
ko-KR Korean (Korea, Republic Of) APOE 유전자 대립유전자 2:존재:검사시점:전혈/조직:명칭결과:분자유전
nl-NL Dutch (Netherlands) APOE-allel 2:identificator:moment:bloed of weefsel:nominaal:moleculair genetisch onderzoek
Synonyms: APOE gen molgen
pt-BR Portuguese (Brazil) APOE gene alelo 2:Ident:Pt:Sg/Tecido:Nom:Genética molecular
Synonyms: ; APOE allele2; Apolipoprotein E gene; AD2; MGC1571; Identity or presence; Point in time; Random; Bld/T; Tissue; Bld/T; Blood; WB; Whole blood; Nominal; PCR; Molecular genetics; II; MOLPATH.MUTATIONS; MOLPATH.MUTATIONS; Molecular pathology
ru-RU Russian (Russian Federation) APOE ген аллель 2:ID:ТчкВрм:Кр/Тк:Ном:МолГен
Synonyms: Аполипопротеина Е ген Идентификатор Кровь Кровь или Ткань Номинальный;Именной Ткань и мазки Точка во времени;Момент
tr-TR Turkish (Turkey) APOE geni allel 2:Tnmlyc:Zmlı:Kan/Dk:Snf:Molgen
zh-CN Chinese (China) APOE 基因 等位基因 2:标识符:时间点:全血/组织:名义型:分子遗传学类实验室方法
Synonyms: Ⅱ AD2;MGC1571;载脂蛋白E基因;阿朴脂蛋白E基因 APOE 等位基因 2 II 全血或组织;血液/组织;血液或组织 分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内,用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 标识;身份标识符;身份标识 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=34732-8