LOINC
Version 2.67

39320-7Abnormal Prion Protein [Presence] in Tissue by ImmunoblotActive

Part Description

LP35078-2   Prion protein.abnormal
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt–Jakob disease, new variant Creutzfeldt–Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann–Sträussler–Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Transmissible spongiform encephalopathy

Fully-Specified Name

Component
Prion protein.abnormal
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
IB

Additional Names

Short Name
Abn Prion Prot Tiss Ql IB
Display Name
Abnormal Prion Protein IB Ql (Tiss)

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.15
Last Updated
Version 2.65
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Updated Answer list type from NORMATIVE to EXAMPLE because the Answers in the list (Positive, Negative) are only examples of possible answers and not an exclusive list
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
朊病毒蛋白.异常:存在情况或阈值:时间点:组织与涂片:序数型:免疫印迹法
nl-NLDutch (NETHERLANDS)
prioneiwit.abnormaal:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunoblotting
fr-BEFrench (BELGIUM)
Protéines prion.anormales:PrThr:Temps ponctuel:Tissu:Ordinal:Immunoblot
fr-CAFrench (CANADA)
Protéines prion.anormales:Présence-Seuil:Temps ponctuel:Tissu:Ordinal:Immunoblot
fr-FRFrench (FRANCE)
Protéine prion anormale:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Immunoblot
it-ITItalian (ITALY)
Proteina prionica.anormale:PrThr:Pt:Tessuto:Ord:IB
ko-KRKorean (KOREA, REPUBLIC OF)
프리온 단백.이상:임의농도:검사시점:조직:순위척도:면역 탁본법
pt-BRPortuguese (BRAZIL)
Proteína prion.anormal:ACnc:Pt:Tecido:Ord:Imunoblot
ru-RURussian (RUSSIAN FEDERATION)
Прионный протеин.аномальный:PrThr:ТчкВрм:Тк:Пор:ИБ
es-ESSpanish (SPAIN)
Proteína priónica anormal:PrThr:Punto temporal:Tejido:Ord:Inmunoblot (IB)
tr-TRTurkish (TURKEY)
Prion protein.anormal:MevcEşik:Zmlı:Doku:Srl:IB

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=39320-7