LOINC
Version 2.71

40505-0Chikungunya virus Ab [Titer] in Serum by Hemagglutination inhibitionActive

Part Descriptions

LP21132-3   Chikungunya virus
A species of ALPHAVIRUS causing an acute dengue-like fever. Source: National Library of Medicine, MeSH 2006

LP21132-3   Chikungunya virus
Chikungunya virus (CHIKV) belongs to the mosquito-borne alphavirus genus, in the family Togaviridae, and was first observed in epidemic form in Africa. Serologically, CHIKV belongs to the Semliki Forest (SF) subgroup of alphaviruses. Infection in humans is characterized by rash, high fever and, its hallmark feature, severe arthritis that can persist for years. CHIKV is a small, spherical, enveloped, positive-strand RNA virus. The virion consists of an envelope and a nucleocapsid. The envelope glycoproteins of alphaviruses are the distinguishing factors for testing. The CHIKV genome encodes for two polyproteins; the non-structural polyprotein consisting of four proteins (nsP1, nsP2, nsP3 and nsP4) and the structural polyprotein consisting of five proteins (Capsid, E3, E2, 6K and E1). CHIKV has spikes on the virion surface that are each formed by three E1-E2 heterodimers, where the E1 glycoproteins mediate fusion and E2 glycoproteins interact with the host receptor. [PMID: 20111039]
CHIKV can be detected between the first and fourth day of infection (the acute phase) using PCR or virus cultivation, and virus-specific IgM and IgG antibodies can be detected during the 8th to the 10th day of infection. Antibody investigation should be performed using serum samples from the acute and convalescent stage. Source: Regenstrief LOINC

LP6304-2   HAI
The hemagglutination-inhibition assay (HAI) can be used to identify subtypes of hemagglutinin producing viruses, such as Influenza. HAI can also be used to identify the subtype-specificity of antibodies against the virus. Normally, Influenza's hemagglutinin glycoprotein binds to receptors on the surface of red blood cells, causing them to agglutinate. If antibodies specific to the virus are present in the patient sample, they will bind to the virus, which prevents the virus from binding to the red blood cells and therefore prevents agglutination. To determine which subtype of virus is present, a viral isolate is tested against a series of antibodies with known subtype specificities. Whichever antibody inhibits red cell agglutination identifies the viral subtype. Similarly, antibody specificity is identified by testing the patient sample against known virus subtypes. [PMID: 24899416] Source: Regenstrief LOINC

Fully-Specified Name

Component
Chikungunya virus Ab
Property
Titr
Time
Pt
System
Ser
Scale
Qn
Method
HAI

Additional Names

Short Name
CHIKV Ab Titr Ser HAI
Display Name
CHIKV Ab HAI (S) [Titer]
Consumer Name Alpha
Chikungunya virus antibody, Blood

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.15
Last Updated
Version 2.32
Order vs. Observation
Both

Member of these Groups

LG51028-5 Chikungunya virus

Language Variants Get Info

zh-CNChinese (China)
基孔肯亚病毒 抗体:滴定度:时间点:血清:定量型:红细胞凝集抑制试验法
nl-NLDutch (Netherlands)
Chikungunya-virus As:titer:moment:serum:kwantitatief:hemagglutinatieremming
fr-BEFrench (Belgium)
Virus Chikungunya Ac:Titre:Temps ponctuel:Sérum:Quantitatif:Inhibition de l'hémagglutination
fr-CAFrench (Canada)
Virus Chikungunya , Ac:Titre:Temps ponctuel:Sérum:Quantitatif:Inhibition de l'hémagglutination
fr-FRFrench (France)
Chikungunya virus Ac:Titre:Ponctuel:Sérum:Numérique:Hémagglutination indirecte
de-DEGerman (Germany)
Chikungunya-Virus Ak:Titr:Pkt:Ser:Qn:HAI
it-ITItalian (Italy)
Chikungunya virus , Ab:Titr:Pt:Siero:Qn:HAI
ko-KRKorean (Korea, Republic of)
치쿤구냐 바이러스 항체:역가:검사시점:혈청:정량:적혈구응집 억제
pt-BRPortuguese (Brazil)
Chikungunya vírus Ac:Título:Pt:Soro:Qn:Inibição da hemaglutinação
es-ESSpanish (Spain)
Virus Chikungunya Anticuerpos:Titulo / Factor de dilución:Punto temporal:Suero:Qn:Inhibición de la Hemaglutinación
tr-TRTurkish (Turkey)
Chikungunya virus Ab:Titr:Zmlı:Ser:Kant:HAI

Example Units

Unit Source
{titer} Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=40505-0