LOINC
Version 2.72

43693-1Varicella zoster virus identified in Skin by Shell vial cultureActive

Part Descriptions

LP14853-3   Varicella zoster virus
Varicella zoster virus (VZV) is a double-stranded alphaherpesvirus that causes seasonal outbreaks of chickenpox and shingles in non-immunized populations. VZV is highly infectious and is transmitted by contact with the ruptured fluid filled blisters and respiratory secretions of infected individuals. Immunity post infection is usually lifelong though the latent virus inhabits the sensory nerve ganglia where it can reactivate causing shingles when immunity declines with aging.[http://jvi.asm.org/content/88/24/13936.full] In the over fifty strains of VZV that have been sequenced it has been found that a single nucleotide polymorphism occurs about every 100 bases. The patterns of polymorphisms in VZV correlate with different geographical regions of infection and is the basis for the classification of viral clades.[https://grose.lab.uiowa.edu/vzv-genomes-and-evolution] Breuer proposed the nomenclature for the VZV clades as 1-5 with the suspected clades VI and VII to be confirmed later. The geographical regions associated with the seven clades are as follows:
Clades 1 and 3-represent the dominant clades of the circulating VZV in Europe and the Americas
Clades 4 and 5-found in Africa
Clade VI found in France, Italy
Clade VII exclusively isolated in the US
Clade 2-Asia from Korea, Japan, China not found in India, Nepal and Bangladesh where clades 4 and 5 were dominant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054591/ Source: Regenstrief LOINC

LP36602-8   Shell vial culture
Virus culture is often more sensitive than trying to detect viruses directly in clinical samples. Shell vial culture is a modification of the conventional cell culture technique for rapid detection of viruses in vitro. The technique involves inoculation of the clinical specimen on to cell monolayer grown on a cover slip in a shell vial culture tube, followed by low speed centrifugation and incubation. This system works on the principle that the low speed centrifugation enhances viral infectivity to the susceptible cells. It is thought that the minor trauma to the cell surface produced as a result of low speed centrifugation mechanical force enhances the viral entry in to the cells, which in turn reduces the total time taken for the virus to produce infection of cells. Virus may be detected by direct fluorescent antibody (DFA) or indirect fluorescent antibody (IFA) staining within hours or days of inoculation. Source: Regenstrief LOINC

Fully-Specified Name

Component
Varicella zoster virus identified
Property
Prid
Time
Pt
System
Skin
Scale
Nom
Method
Shell vial culture

Additional Names

Short Name
VZV Skin Shell Vial Cult
Display Name
VZV identified Shell vial culture Nom (Skin)
Consumer Name Alpha
Varicella zoster virus (VZV; Chickenpox) culture, Skin

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.17
Last Updated
Version 2.21
Order vs. Observation
Both

Member of these Groups

LG32750-8 Varicella zoster virus

Language Variants Get Info

zh-CNChinese (China)
水痘带状疱疹病毒 已鉴定的:存在与否或特征标识:时间点:皮肤:名义型:细胞培养瓶培养法
nl-NLDutch (Netherlands)
varicella-zostervirus geïdentificeerd:identificator:moment:huid:nominaal:Shell vial'-kweek
fr-BEFrench (Belgium)
Virus varicelle-zona Identifiées:Présence ou identité:Temps ponctuel:Peau:Nominal:Culture sur lame en flacon
fr-CAFrench (Canada)
Virus varicelle-zona , Identifiés:Présence ou identité:Temps ponctuel:Peau:Nominal:Culture sur lame en flacon
fr-FRFrench (France)
Varicelle zona virus identifié:Identification:Ponctuel:Peau:Résultat nominal:Culture fiole de coquille
it-ITItalian (Italy)
Varicella zoster, virus , identificato:Prid:Pt:Pelle:Nom:Shell vial, coltura
pt-BRPortuguese (Brazil)
Identificação de Varicella zoster vírus:Ident:Pt:Pele:Nom:Shell vial cultura
es-MXSpanish (Mexico)
Virus de varicela zóster identificado:Presencia o identidad:Punto temporal:Piel:Nominal:Cultivo de viales de concha
es-ESSpanish (Spain)
Virus Varicella zoster identificado:Presencia o identidad:Punto temporal:Piel:Nom:Cultivos en "shell vial"

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=43693-1