LOINC
Version 2.73

44332-5Jo-1 extractable nuclear IgG Ab [Presence] in SerumActive

Part Description

LP16719-4   Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books:NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. [PMID:23573256] Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. [PMID:17392287] Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Fully-Specified Name

Component
Jo-1 extractable nuclear Ab.IgG
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method

Additional Names

Short Name
ENA Jo1 IgG Ser Ql
Display Name
Jo-1 extractable nuclear IgG Ql (S)
Consumer Name Alpha
Jo-1 extractable nuclear IgG antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.17
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common US Lab Results Rank
2158

Member of these Groups

LG17624-4 Jo-1 extractable nuclear Ab.IgG|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
Jo-1 可提取性核 抗体.IgG:存在情况或阈值:时间点:血清:序数型:
nl-NLDutch (Netherlands)
jo-1 extraheerbaar nucleair As.IgG:aanwezigheid:moment:serum:ordinaal:
fr-BEFrench (Belgium)
Jo-1 nucléaire soluble Anticorps. IgG:PrThr:Temps ponctuel:Sérum:Ordinal:
fr-CAFrench (Canada)
Jo-1 nucléaire soluble , IgG:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:
fr-FRFrench (France)
Jo-1 anticorps IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:
it-ITItalian (Italy)
Jo-1, nucleare estraibile Ab.IgG:PrThr:Pt:Siero:Ord:
pt-BRPortuguese (Brazil)
Jo-1 Ac.IgG:ACnc:Pt:Soro:Ord:
ru-RURussian (Russian Federation)
Jo-1 экстрагируемый ядерный Ат.IgG:PrThr:ТчкВрм:Сыв:Пор:
es-MXSpanish (Mexico)
Ab.IgG nuclear extraíble con Jo-1:Presencia o umbral:Punto temporal:Suero:Ordinal:
es-ESSpanish (Spain)
Jo-1 IgG:PrThr:Punto temporal:Suero:Ord:
tr-TRTurkish (Turkey)
Jo-1 öztlenebilir çekirdek Ab.IgG:MevcEşik:Zmlı:Ser:Srl:

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=44332-5