LOINC
Version 2.73

46718-3Aquaporin 4 water channel IgG Ab [Presence] in Cerebral spinal fluidActive

Part Description

LP39188-5   Aquaporin 4 water channel Ab.IgG
The water channel aquaporin 4 (AQP4) receptor regulates the water homeostasis in the central nervous system (CNS). Autoantibodies to the AQP4 receptor bind to the receptor and cause neuromyelitis optica (NMO) which is an idiopathic, severe, demyelinating disease of the CNS that primarily affects the optic nerve and spinal cord. Before the discovery of the AQP4 receptor antibody NMO was often misdiagnosed as a variant of multiple sclerosis (MS). With improved clinical laboratory tests and distinct immunological and pathological attributes the two diseases are less often confused. Distinguishing MS and NMO is especially important because they have different treatments. Treatment for NMO includes corticosteroids and plasmapheresis; typical medications used to treat MS, such as beta-interferon and glatiramer acetate are not effective against NMO. During the disease process, the aquaporin 4 receptor antibody binds to the aquaporin 4 receptor initiating the activation of complement, inflammatory demyelination and necrosis. Eighty to ninety percent of patients with NMO experience recurrent episodes of optic neuritis and myelitis. Many patients with NMO also have other autoimmune diseases including thyroiditis, systemic lupus erythematosus
and Sjogren's syndrome.[PMID:17706564] Detection of APQ4-IgG is indicative of a relapsing disease. Immediate treatment with immunosuppressive drugs reduces the frequency and disability of future attacks. [http://labmed.ucsf.edu/labmanual/db/dataall/tests/1424.html] Source: Regenstrief LOINC

Fully-Specified Name

Component
Aquaporin 4 water channel Ab.IgG
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method

Additional Names

Short Name
AQP4 H2O channel IgG CSF Ql
Display Name
Aquaporin 4 water channel IgG Ql (CSF)
Consumer Name Alpha
Aquaporin 4 water channel IgG antibody, Spinal fluid

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.19
Last Updated
Version 2.73
Change Reason
Release 2.67: COMPONENT: Updated "receptor" to "water channel" per current scientific nomenclature; Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common US Lab Results Rank
8092

Member of these Panels

LOINC Long Common Name
94353-0 Myelopathy autoimmune Ab panel - Cerebral spinal fluid

Member of these Groups

LG50124-3 Aquaporin 4 water channel Ab.IgG|PrThr|Pt|CSF

Language Variants Get Info

zh-CNChinese (China)
水通道蛋白 4 受体 抗体.IgG:存在情况或阈值:时间点:脑脊液:序数型:
nl-NLDutch (Netherlands)
aquaporine 4 waterkanaal As.IgG:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:
et-EEEstonian (Estonia)
Akvaporiin 4 retseptor antikehad.IgG:PrThr:Pt:CSF:Ord:
fr-BEFrench (Belgium)
Récepteur Aquaporin 4 Anticorps. IgG:PrThr:Temps ponctuel:LCR:Ordinal:
fr-CAFrench (Canada)
Récepteur Aquaporin 4 , IgG:Présence-Seuil:Temps ponctuel:LCR:Ordinal:
fr-FRFrench (France)
Aquaporine 4 récepteur anticorps IgG:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:
it-ITItalian (Italy)
Acquaporina 4, canale idrico Ab.IgG:PrThr:Pt:LCS:Ord:
pt-BRPortuguese (Brazil)
Neuromyelitis optica Ac.IgG:ACnc:Pt:LCR:Ord:
ru-RURussian (Russian Federation)
Аквапорина 4 рецепторы Ат.IgG:PrThr:ТчкВрм:ЦСЖ:Пор:
es-MXSpanish (Mexico)
Acuaporina 4 canal de agua Ab.IgG:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:
es-ESSpanish (Spain)
Receptor de Acuaporina 4 IgG:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:
tr-TRTurkish (Turkey)
Akuaporin 4 reseptörü Ab.IgG:MevcEşik:Zmlı:BOS:Srl:

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=46718-3