50359-9
Phenyllactate/Creatinine [Molar ratio] in 24 hour Urine
Active
Part Descriptions
LP18451-2 Phenyllactate
L-3-Phenyllactic acid (or PLA) is a chiral aromatic compound involved in phenylalanine metabolism. It is likely produced from phenylpyruvate via the action of lactate dehydrogenase. The D-form of this organic acid is typically derived from bacterial sources while the L-form is almost certainly endogenous. Levels of phenyllactate are normally very low in blood or urine. High levels of PLA in the urine or blood are often indicative of phenylketonuria (PKU) and hyperphenylalaninemia (HPA). PKU is due to lack of the enzyme phenylalanine hydroxylase (PAH), so that phenylalanine is converted not to tyrosine but to phenylpyruvic acid (a precursor of phenylactate). In particular, excessive phenylalanine is typically metabolized into phenylketones through, a transaminase pathway route involving glutamate. Metabolites of this transamination reaction include phenylacetate, phenylpyruvate and phenethylamine. In persons with PKU, dietary phenylalanine either accumulates in the body or some of it is converted to phenylpyruvic acid and then to phenyllactate through the action of lactate dehydrogenase. Individuals with PKU tend to excrete large quantities of phenylpyruvate, phenylacetate and phenyllactate, along with phenylalanine, in their urine. If untreated, mental retardation effects and microcephaly are evident by the first year along with other symptoms which include: unusual irritability, epileptic seizures and skin lesions. Hyperactivity, EEG abnormalities and seizures, and severe learning disabilities are major clinical problems later in life. A "musty or mousy" odor of skin, hair, sweat and urine (due to phenylacetate accumulation); and a tendency to hypopigmentation and eczema are also observed. The neural-development effects of PKU are primarily due to the disruption of neurotransmitter synthesis. In particular, phenylalanine is a large, neutral amino acid which moves across the blood-brain barrier (BBB) via the large neutral amino acid transporter (LNAAT). Excessive phenylalanine in the blood saturates the transporter. Thus, excessive levels of phenylalanine significantly decrease the levels of other LNAAs in the brain. But since these amino acids are required for protein and neurotransmitter synthesis, phenylalanine accumulation disrupts brain development, leading to mental retardation.
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database, Human Metabolome Database
LP32035-5 Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas.
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database, Creatinine
Fully-Specified Name
- Component
- Phenyllactate/Creatinine
- Property
- SRto
- Time
- 24H
- System
- Urine
- Scale
- Qn
- Method
Additional Names
- Short Name
- Phenyllactate/Creat 24h Ur-sRto
- Display Name
- Phenyllactate/Creatinine (24H U) [Molar ratio]
- Consumer Name Alpha Get Info
- Phenyllactate/Creatinine, Urine
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.22
- Last Updated
- Version 2.70
- Order vs. Observation
- Both
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG35327-2 | Phenyllactate/Creatinine| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-AT | German (Austria) | Synonyms: PLAKT/Krea-Rto/24hU |
| es-MX | Spanish (Mexico) | Fenilactato / Creatinina: |
| es-ES | Spanish (Spain) | Fenilactato/Creatinina: Synonyms: Cuantitativo |
| fr-CA | French (Canada) | Phényllactate/Créatinine: |
| fr-FR | French (France) | 3-phényllactate/créatinine: |
| fr-BE | French (Belgium) | Phényllactate/Créatinine: |
| it-IT | Italian (Italy) | Fenillattato/Creatinina: Synonyms: 24 Ore Chimica Rapporto di sostanza |
| nl-NL | Dutch (Netherlands) | fenyllactaat/creatinine: Synonyms: 24U kreatinine |
| pl-PL | Polish (Poland) | Fenylomleczan/kreatynina: |
| pt-BR | Portuguese (Brazil) | Fenilacetato/Creatinina: Synonyms: Phenyllactic acid; |
| ru-RU | Russian (Russian Federation) | Фениллактат/Креатинин: Synonyms: Количественный Мольная доля; |
| tr-TR | Turkish (Turkey) | Fenillaktat/Kreatinin: Synonyms: SubsOranı |
| zh-CN | Chinese (China) | 苯乳酸/肌酐: Synonyms: 1天; |
Example Units
| Unit | Source |
|---|---|
| mmol/mol{creat} | Example UCUM Units |
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