LOINC
Version 2.73

5281-1Polio virus 1 neutralizing antibody [Titer] in Serum by Neutralization testActive

Part Descriptions

LP6416-4   Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. [PMID:32170698] This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. [PMID:169804] Source: Regenstrief LOINC

LP207365-0   Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

Fully-Specified Name

Component
Polio virus 1 Ab.Neut
Property
Titr
Time
Pt
System
Ser
Scale
Qn
Method
Neut

Additional Names

Short Name
PV1 NAb Titr Ser Nt
Display Name
Polio virus 1 neut ab Neut test (S) [Titer]
Consumer Name Alpha
Polio virus 1 neutralizing antibody, Blood

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 1.0
Last Updated
Version 2.73
Change Reason
Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.;
Order vs. Observation
Both
Common US Lab Results Rank
5873

Member of these Panels

LOINC Long Common Name
41506-7 Polio virus neutralizing Ab panel - Serum by Neutralization test

Member of these Groups

LG32765-6 Polio virus

Language Variants Get Info

zh-CNChinese (China)
脊髓灰质炎病毒 1 型 抗体.中和:滴定度:时间点:血清:定量型:中和试验
nl-NLDutch (Netherlands)
Poliovirus 1 As.neutraliserend:titer:moment:serum:kwantitatief:neutralisatietest
fr-CAFrench (Canada)
Poliovirus 1 Ac.neut:Titre:Temps ponctuel:Sérum:Quantitatif:Test de neutralisation
fr-FRFrench (France)
Polio virus 1 Ac:Titre:Ponctuel:Sérum:Numérique:Neutralisation
de-DEGerman (Germany)
Polio-Virus 1 Ak.neutralisierend:Titer:Zeitpunkt:Serum:Quantitativ:Neutralisationstest
it-ITItalian (Italy)
Polio virus 1 Ab.Neut:Titr:Pt:Siero:Qn:Neut
ko-KRKorean (Korea, Republic of)
폴리오 바이러스 1 항체:역가:검사시점:혈청:정량:중화
pt-BRPortuguese (Brazil)
Polio vírus 1 Ac:Título:Pt:Soro:Qn:Teste de neutralização
es-ARSpanish (Argentina)
[anticuerpo anti - ] virus 1 de la poliomielitis [Ac]:factor de dilución (titulación):punto en el tiempo:suero:cuantitativo:neutralización
es-MXSpanish (Mexico)
Virus de la poliomielitis 1 Ab:Título:Punto temporal:Suero:Cuantitativo:Prueba de neutralización
es-ESSpanish (Spain)
Polio virus 1 Anticuerpos antineutrófilos:Titulo / Factor de dilución:Punto temporal:Suero:Qn:Prueba de neutralización

Example Units

Unit Source
{titer} Example UCUM Units
titer REGENSTRIEF

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=5281-1