LOINC
Version 2.67

53032-9U1 small nuclear ribonucleoprotein 70kD Ab [Presence] in SerumActive

Part Description

LP69897-4   U1 small nuclear ribonucleoprotein 70kD
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1–70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. [PMID: 24158973] In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. [PMID: 20015915] Source: Regenstrief LOINC, PMID: 24158973

Fully-Specified Name

Component
U1 small nuclear ribonucleoprotein 70kD Ab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method

Additional Names

Short Name
U1 snRNP70 Ab Ser Ql
Display Name
U1 small nuclear ribonucleoprotein 70kD Ab Ql (S)

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.24
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Member of these Groups

LG21400-3 U1 small nuclear ribonucleoprotein 70kD Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (CHINA)
U1 小细胞核核糖核蛋白 70kD 抗体:存在情况或阈值:时间点:血清:序数型:
nl-NLDutch (NETHERLANDS)
u1 small nucleair ribonucleoproteïne 70kD As:aanwezigheid:moment:serum:ordinaal:
fr-BEFrench (BELGIUM)
Petite particule nucléaire ribonucléoprotéique U1 70kD Ac:PrThr:Temps ponctuel:Sérum:Ordinal:
fr-CAFrench (CANADA)
Petite particule nucléaire ribonucléoprotéique U1 70kD , Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:
fr-FRFrench (FRANCE)
RNP 70kD anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:
de-ATGerman (AUSTRIA)
U1-snRNP-70-AK ql.
de-DEGerman (GERMANY)
U1 kleine nukleäre Ribonukleoprotein-70kd Ak:AKnz:Pkt:Ser:Ord:
it-ITItalian (ITALY)
U1, piccola ribonucleoproteina nucleare 70kD , Ab:PrThr:Pt:Siero:Ord:
pt-BRPortuguese (BRAZIL)
U1 Ribonucleoproteína núcleo pequeno 70kD Ac.IgG:ACnc:Pt:Soro:Ord:
ru-RURussian (RUSSIAN FEDERATION)
U1 малый ядерный рибонуклеопротеин 70кД Ат:PrThr:ТчкВрм:Сыв:Пор:
es-ESSpanish (SPAIN)
U1 ribonucleoproteína nuclear pqueña de 70kD Anticuerpos:PrThr:Punto temporal:Suero:Ord:
tr-TRTurkish (TURKEY)
U1 kçk nükleer ribonükleoprotein 70kD Ab:MevcEşik:Zmlı:Ser:Srl:

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53032-9