LOINC
Version 2.67

53981-7Centromere protein B Ab [Presence] in SerumActive

Part Description

LP71684-2   Centromere protein B Ab
Major centromere autoantigen B, also known as centromere protein B or CENP-B, is encoded by the CENPB gene located on chromosome 20p13. CENP-B interacts with chromosomal centromeric heterochromatin and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. [UniProt: P07199] CENP-B plays a direct role in stablizing CENP-C, which is a kinetochore assembly nucleator, and recruiting CENP-A, which marks and maintains centromere position. Chromosomes that have centromeres without bound CENP-B, including the human Y chromosome, are more likely to missegregate at much higher rates than chromosomes with CENP-B containing centromeres. [PMID: 25942623] Autoantibodies to both CENP-A and CENP-B are markers for scleroderma and other rheumatic diseases. [PMID: 17210244] Source: Regenstrief LOINC, UniProt: P07199

Fully-Specified Name

Component
Centromere protein B Ab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method

Additional Names

Short Name
Centromere B Ab Ser Ql
Display Name
Centromere protein B Ab Ql (S)

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Member of these Groups

LG21820-2 Centromere protein B Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (CHINA)
着丝点蛋白 B 抗体:存在情况或阈值:时间点:血清:序数型:
nl-NLDutch (NETHERLANDS)
centromeereiwit B As:aanwezigheid:moment:serum:ordinaal:
et-EEEstonian (ESTONIA)
Tsentromeer B vastased antikehad:PrThr:Pt:S:Ord:
fr-BEFrench (BELGIUM)
Centromère. Protéine B Ac:PrThr:Temps ponctuel:Sérum:Ordinal:
fr-CAFrench (CANADA)
Centromère protéine B , Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:
fr-FRFrench (FRANCE)
Centromère protéine B anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:
de-ATGerman (AUSTRIA)
CENP-B-AK ql.
de-DEGerman (GERMANY)
Zentromerprotein B Ak:AKnz:Pkt:Ser:Ord:
it-ITItalian (ITALY)
Centromero, proteina B , Ab:PrThr:Pt:Siero:Ord:
pt-BRPortuguese (BRAZIL)
Proteína B do Centrômero Ac:ACnc:Pt:Soro:Ord:
ru-RURussian (RUSSIAN FEDERATION)
Центромерный протеин B Ат:PrThr:ТчкВрм:Сыв:Пор:
es-ESSpanish (SPAIN)
Proteína B del centrómero Anticuerpos:PrThr:Punto temporal:Suero:Ord:
tr-TRTurkish (TURKEY)
Sentromer protein B Ab:MevcEşik:Zmlı:Ser:Srl:

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53981-7