LOINC
Version 2.67

54003-9Human upstream binding factor Ab [Presence] in Serum by ImmunofluorescenceActive

Term Description

This entity has two names: "nucleolar organizing region (NOR) 90" versus "human upstream binding factor (hUBF)". Both names are right, and the literature looking for the antibody in autoimmune patients almost uniformly includes both names and the historical context. NOR90 stuck because it was called that by the author of the original finding in autoimmune patients (Rodriguez-Sanchez, et al, 1987), but a few years later (1994), the antigen was found to be identical to already characterized hUBF. So we are stuck with the 2 names. hUBF is more technically specific, and at least one recent review calls it "anti-hUBF, formerly anti-NOR 90" (Journal of Dermatology 2010; 37: 42-53). So we will use that as its primary name.
Source: Regenstrief LOINC

Part Description

LP71704-8   Human upstream binding factor
Human upstream binding factor (hUBF) is a nucleolar protein that plays a key role in rRNA production. The protein regulates rDNA transcription and also promotes rRNA synthesis. DNA binding to hUBF has the potential to alter chromatin by inducing chromatin remodeling. [PMID: 25965800] Autoantibodies to hUBF (anti-hUBF) are associated with various connective tissue diseases, including systemic sclerosis, Raynaud's disease, rheumatoid arthritis and systemic lupus erythematosus. Anti-hUBF antibodies have also been associated with some malignancies. Anti-hUBF and anti-nucleolus-organizing region (NOR) 90 antibodies were originally described as distinct entities but later were recognized as being the same. [PMID: 20175839] Source: Regenstrief LOINC, PMID: 20175839

Fully-Specified Name

Component
Human upstream binding factor Ab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
IF

Additional Names

Short Name
hUBF Ab Ser Ql IF
Display Name
Human upstream binding factor Ab IF Ql (S)

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups

LG21896-2 Human upstream binding factor Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (CHINA)
人上游结合因子 抗体:存在情况或阈值:时间点:血清:序数型:免疫荧光法
nl-NLDutch (NETHERLANDS)
Humaan upstream binding factor As:aanwezigheid:moment:serum:ordinaal:immunofluorescentie
et-EEEstonian (ESTONIA)
NOR-90 antikehad:PrThr:Pt:S:Ord:IF
fr-BEFrench (BELGIUM)
Human upstream binding factor Ac:PrThr:Temps ponctuel:Sérum:Ordinal:Immunofluorescence
fr-CAFrench (CANADA)
NOR-90 , Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunofluorescence
fr-FRFrench (FRANCE)
NOR-90 anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunofluorescence
de-ATGerman (AUSTRIA)
NOR-90 AK ql.
de-DEGerman (GERMANY)
NOR-90 Ak:AKnz:Pkt:Ser:Ord:IF
it-ITItalian (ITALY)
Fattore umano a monte legante , Ab:PrThr:Pt:Siero:Ord:IF
pt-BRPortuguese (BRAZIL)
NOR-90 Ac:ACnc:Pt:Soro:Ord:Imunofluorescência
ru-RURussian (RUSSIAN FEDERATION)
Человеческий upstream binding factor Ат:PrThr:ТчкВрм:Сыв:Пор:ИФ
es-ESSpanish (SPAIN)
factor de unión upstream humano Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inmunofluorescencia (IF)
tr-TRTurkish (TURKEY)
Human upstream bağlayıcı factor Ab:MevcEşik:Zmlı:Ser:Srl:IF

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=54003-9