Version 2.76

Part Description

LP71719-6   U1 small nuclear ribonucleoprotein A
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1-70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. PMID: 24158973 In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. PMID: 20015915 Source: Regenstrief LOINC, PMID: 24158973

Fully-Specified Name

Component
U1 small nuclear ribonucleoprotein A Ab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method

Additional Names

Short Name
U1 snRNP-A Ab Ser Ql
Display Name
U1 small nuclear ribonucleoprotein A Ab Ql (S)
Consumer Name Alpha Get Info
U1 Small Nuclear Ribonucleoprotein A antibody, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG21924-2 U1 small nuclear ribonucleoprotein A Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: U1-snRNP-A-AK qual.
de-DE German (Germany) U1 kleine nukleäre Ribonukleoprotein-A Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:
es-ES Spanish (Spain) U1 ribonucleoproteína nuclear pequeña A Anticuerpos:PrThr:Punto temporal:Suero:Ord:
es-MX Spanish (Mexico) U1 ribonucleoproteína nuclear sub A Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:
fr-CA French (Canada) Petite particule nucléaire ribonucléoprotéique U1 A , Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:
fr-FR French (France) U1 RNP A anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:
fr-BE French (Belgium) Petite particule nucléaire ribonucléoprotéique U1 A Ac:PrThr:Temps ponctuel:Sérum:Ordinal:
Synonyms: Anticorps
it-IT Italian (Italy) U1, piccola ribonucleoproteina nucleare A Ab:PrThr:Pt:Siero:Ord:
Synonyms: anticorpo Piccola ribonucleoproteina nucleare U1 Piccola ribonucleoproteina nucleare U1 A Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) u1 small nucleair ribonucleoproteïne A As:aanwezigheid:moment:serum:ordinaal:
Synonyms: antistof; antilichaam
pt-BR Portuguese (Brazil) U1 Ribonucleoproteína núcleo pequeno A Ac:ACnc:Pt:Soro:Ord:
Synonyms: ; U1 snRNP-A; U1 RNP; U1 snRNP; U1RNP; Nuc; Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Ribonuclear protein; Serology
ru-RU Russian (Russian Federation) U1 малый ядерный рибонуклеопротеин A Ат:PrThr:ТчкВрм:Сыв:Пор:
Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) U1 kçk nükleer ribonükleoprotein A Ab:MevcEşik:Zmlı:Ser:Srl:
Synonyms: Ak Çekirdek Mevcut
zh-CN Chinese (China) U1 小细胞核核糖核蛋白 A 抗体:存在情况或阈值:时间点:血清:序数型:
Synonyms: A 型 A 型抗体 Ab;自身抗体 RNP snRNP U1 RNP A;U1 snRNP A;U1 小细胞核核糖核蛋白 A;U1 small nuclear ribonucleoprotein A;U1RNP A U1 RNP;U1 snRNP;U1 小细胞核核糖核蛋白;U1 small nuclear ribonucleoprotein;U1RNP 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 小分子核糖核蛋白体 小分子细胞核核糖核蛋白 小核核糖核蛋白(Small nuclear ribonucleoprotein,snRNP) 时刻;随机;随意;瞬间 核;胞核 核内小核糖核蛋白 核微小核糖核蛋白 核糖核蛋白(Ribonucleoprotein,Ribonuclear protein,RNP) 核蛋白 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目(非微生物学);血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验(非微生物学);血清学试验类 (非微生物学);血清类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=54032-8