Version 2.73

56731-3Jo-1 extractable nuclear Ab [Presence] in Serum by ImmunoblotActive

Part Description

LP16719-4   Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books:NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. [PMID:23573256] Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. [PMID:17392287] Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Fully-Specified Name

Jo-1 extractable nuclear Ab

Additional Names

Short Name
ENA Jo1 Ab Ser Ql IB
Display Name
Jo-1 extractable nuclear Ab IB Ql (S)
Consumer Name Alpha
Jo-1 extractable nuclear antibody, Blood

Basic Attributes

First Released
Version 2.29
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Common US Lab Results Rank

Member of these Groups

LG5369-6 Jo-1 extractable nuclear Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
Jo-1 可提取性核 抗体:存在情况或阈值:时间点:血清:序数型:免疫印迹法
nl-NLDutch (Netherlands)
jo-1 extraheerbaar nucleair As:aanwezigheid:moment:serum:ordinaal:immunoblotting
fr-BEFrench (Belgium)
Jo-1 nucléaire soluble Ac:PrThr:Temps ponctuel:Sérum:Ordinal:Immunoblot
fr-CAFrench (Canada)
Jo-1 nucléaire soluble , Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoblot
fr-FRFrench (France)
Jo-1 anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoblot
de-DEGerman (Germany)
Jo-1 extrahierbarer nukleärer Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Immunoblot
it-ITItalian (Italy)
Jo-1, nucleare estraibile Ab:PrThr:Pt:Siero:Ord:IB
pt-BRPortuguese (Brazil)
Jo-1 Ac:#N/A:Pt:Soro:Ord:Imunoblot
ru-RURussian (Russian Federation)
Jo-1 экстрагируемый ядерный Ат:PrThr:ТчкВрм:Сыв:Пор:ИБ
es-MXSpanish (Mexico)
Ab nuclear extraíble Jo-1:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunotransferencia
es-ESSpanish (Spain)
Jo-1 Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inmunoblot (IB)
tr-TRTurkish (Turkey)
Jo-1 öztlenebilir çekirdek Ab:MevcEşik:Zmlı:Ser:Srl:IB

LOINC FHIR® API Example - CodeSystem Request Get Info