LOINC
Version 2.73

63242-2Ganglioside GM1 IgG Ab [Presence] in Cerebral spinal fluid by ImmunoassayActive

Part Descriptions

LP36423-9   Ganglioside GM1
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. [PMID:21214559] Source: Regenstrief LOINC, PMID: 2121455

LP222219-0   Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC, PMID: 2121455

Fully-Specified Name

Component
Ganglioside GM1 Ab.IgG
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
IA

Additional Names

Short Name
GM1 Gangl IgG CSF Ql IA
Display Name
Ganglioside GM1 IgG IA Ql (CSF)
Consumer Name Alpha
Ganglioside GM1 IgG antibody, Spinal fluid

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.36
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups

LG26349-7 Ganglioside GM1 Ab.IgG|PrThr|Pt|CSF

Language Variants Get Info

zh-CNChinese (China)
神经节苷脂 GM1 抗体.IgG:存在情况或阈值:时间点:脑脊液:序数型:免疫测定法
nl-NLDutch (Netherlands)
ganglioside GM1 As.IgG:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:immunoassay
et-EEEstonian (Estonia)
Gangliosiid GM1 antikehad.IgG:PrThr:Pt:CSF:Ord:IA
fr-BEFrench (Belgium)
Ganglioside GM1 Anticorps. IgG:PrThr:Temps ponctuel:LCR:Ordinal:IA
fr-CAFrench (Canada)
Ganglioside GM1 , IgG:Présence-Seuil:Temps ponctuel:LCR:Ordinal:IA
fr-FRFrench (France)
Ganglioside GM1 anticorps IgG:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Immunoanalyse
it-ITItalian (Italy)
Ganglioside GM1 Ab.IgG:PrThr:Pt:LCS:Ord:IA
ru-RURussian (Russian Federation)
Ганглиозид GM1 Ат.IgG:PrThr:ТчкВрм:ЦСЖ:Пор:IA
es-MXSpanish (Mexico)
Gangliósido GM1 Ab.IgG:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Inmunoensayo
es-ESSpanish (Spain)
Gangliósido GM1 IgG:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:IA
tr-TRTurkish (Turkey)
Gangliozid GM1 Ab.IgG:MevcEşik:Zmlı:BOS:Srl:İA

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https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=63242-2