LOINC
Version 2.73

63267-9Jo-1 extractable nuclear Ab [Presence] in Cerebral spinal fluid by ImmunoassayActive

Part Description

LP16719-4   Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books:NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. [PMID:23573256] Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. [PMID:17392287] Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Fully-Specified Name

Component
Jo-1 extractable nuclear Ab
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
IA

Additional Names

Short Name
ENA Jo1 Ab CSF Ql IA
Display Name
Jo-1 extractable nuclear Ab IA Ql (CSF)
Consumer Name Alpha
Jo-1 extractable nuclear antibody, Spinal fluid

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.36
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups

LG20855-9 Jo-1 extractable nuclear Ab|PrThr|Pt|CSF

Language Variants Get Info

zh-CNChinese (China)
Jo-1 可提取性核 抗体:存在情况或阈值:时间点:脑脊液:序数型:免疫测定法
nl-NLDutch (Netherlands)
jo-1 extraheerbaar nucleair As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:immunoassay
fr-BEFrench (Belgium)
Jo-1 nucléaire soluble Ac:PrThr:Temps ponctuel:LCR:Ordinal:IA
fr-CAFrench (Canada)
Jo-1 nucléaire soluble , Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:IA
fr-FRFrench (France)
Jo-1 anticorps:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Immunoanalyse
it-ITItalian (Italy)
Jo-1, nucleare estraibile Ab:PrThr:Pt:LCS:Ord:IA
ru-RURussian (Russian Federation)
Jo-1 экстрагируемый ядерный Ат:PrThr:ТчкВрм:ЦСЖ:Пор:IA
es-MXSpanish (Mexico)
Ab nuclear extraíble Jo-1:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Inmunoensayo
es-ESSpanish (Spain)
Jo-1 Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:IA
tr-TRTurkish (Turkey)
Jo-1 öztlenebilir çekirdek Ab:MevcEşik:Zmlı:BOS:Srl:İA

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=63267-9