LOINC
Version 2.73

63316-4U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by ImmunoassayActive

Part Description

LP69897-4   U1 small nuclear ribonucleoprotein 70kD
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1-70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. [PMID:24158973] In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. [PMID:20015915] Source: Regenstrief LOINC, PMID: 24158973

Fully-Specified Name

Component
U1 small nuclear ribonucleoprotein 70kD Ab
Property
ACnc
Time
Pt
System
Ser
Scale
Qn
Method
IA

Additional Names

Short Name
U1 snRNP70 Ab Ser IA-aCnc
Display Name
U1 small nuclear ribonucleoprotein 70kD Ab IA Qn (S)
Consumer Name Alpha
U1 small nuclear ribonucleoprotein 70kD antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.36
Last Updated
Version 2.73
Change Reason
The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common US Lab Results Rank
8812

Member of these Groups

LG24688-0 U1 small nuclear ribonucleoprotein 70kD Ab|ACnc|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
U1 小细胞核核糖核蛋白 70kD 抗体:任意型浓度:时间点:血清:定量型:免疫测定法
nl-NLDutch (Netherlands)
u1 small nucleair ribonucleoproteïne 70kD As:eenheid/volume:moment:serum:kwantitatief:immunoassay
fr-BEFrench (Belgium)
Petite particule nucléaire ribonucléoprotéique U1 70kD Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:IA
fr-CAFrench (Canada)
Petite particule nucléaire ribonucléoprotéique U1 70kD , Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:IA
fr-FRFrench (France)
RNP 70kD anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Immunoanalyse
it-ITItalian (Italy)
U1, piccola ribonucleoproteina nucleare 70kD Ab:ACnc:Pt:Siero:Qn:IA
ru-RURussian (Russian Federation)
U1 малый ядерный рибонуклеопротеин 70кД Ат:ПроизвКонц:ТчкВрм:Сыв:Колич:IA
es-MXSpanish (Mexico)
Ribonucleoproteína nuclear sub U1 70kD Ab:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Inmunoensayo
es-ESSpanish (Spain)
U1 ribonucleoproteína nuclear pqueña de 70kD Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:IA
tr-TRTurkish (Turkey)
U1 kçk nükleer ribonükleoprotein 70kD Ab:SçKons:Zmlı:Ser:Kant:İA

Example Units

Unit Source
[arb'U]/mL Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=63316-4