LOINC
Version 2.73

6896-5cloZAPine [Mass/volume] in Serum or PlasmaActive

Term Description

Per ARUP, clozapine levels are used to evaluate toxicity and monitor therapeutic drug levels. 100 ng/mL is the minimum therapeutic threshold, and levels > 1200 ng/mL increase the likelihood of adverse effects such as seizures.
Source: Regenstrief LOINC

Part Descriptions

LP17236-8   cloZAPine
Clozapine (sold as Clozaril ®, Leponex ®, Fazaclo ®) was the first of the atypical antipsychotics to be developed. It was approved by the United States Food and Drug Administration (FDA) in 1989 and is the only FDA-approved medication indicated for treatment-resistant schizophrenia and for reducing the risk of suicidal behaviour in patients with schizophrenia. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Clozapine (Wikipedia)

LP17236-8   cloZAPine
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. Source: National Library of Medicine, MeSH 2006

Fully-Specified Name

Component
cloZAPine
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
cloZAPine SerPl-mCnc
Display Name
cloZAPine [Mass/Vol]
Consumer Name Alpha
cloZAPine, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0h(2)
Last Updated
Version 2.73
Order vs. Observation
Both
Common US Lab Results Rank
2327
Common Orders Rank
189

Member of these Panels

LOINC Long Common Name
65632-2 cloZAPine and Norclozapine panel - Serum or Plasma

Member of these Groups

LG48379-8 Clozapine|Pt|Ser/Plas

Language Variants Get Info

zh-CNChinese (China)
氯氮平:质量浓度:时间点:血清/血浆:定量型:
nl-NLDutch (Netherlands)
clozapine:massa/volume:moment:serum of plasma:kwantitatief:
et-EEEstonian (Estonia)
Klosapiin:MCnc:Pt:S/P:Qn:
fr-BEFrench (Belgium)
Clozapine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-CAFrench (Canada)
Clozapine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FRFrench (France)
Clozapine:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
de-DEGerman (Germany)
Clozapin:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
it-ITItalian (Italy)
Clozapina:MCnc:Pt:Siero/Plasma:Qn:
ko-KRKorean (Korea, Republic of)
클로자핀:질량농도:검사시점:혈청/혈장:정량:
pt-BRPortuguese (Brazil)
Clozapina:MCnc:Pt:Sor/Plas:Qn:
ru-RURussian (Russian Federation)
Клозапин:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
es-ARSpanish (Argentina)
clozapina:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-MXSpanish (Mexico)
clozapina:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
es-ESSpanish (Spain)
Clozapina:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
tr-TRTurkish (Turkey)
Klozapine:KütlKons:Zmlı:Ser/Plaz:Kant:

Example Units

Unit Source
ug/L eCHN
ng/mL Example UCUM Units
ng/mL REGENSTRIEF

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=6896-5