6926-0

Ganglioside GM1 IgM Ab [Titer] in Serum

Active

Part Descriptions

LP36423-9   Ganglioside GM1
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. [PMID: 21214559] Source: Regenstrief LOINC, PMID: 2121455

LP222219-0   Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC

Fully-Specified Name

Component

Ganglioside GM1 Ab.IgM

Property

Titr

Time

Pt

System

Ser

Scale

Qn

Method

Additional Names

Short Name

GM1 Gangl IgM Titr Ser

Display Name

Ganglioside GM1 IgM (S) [Titer]

Consumer Name Alpha

Ganglioside GM1 IgM antibody, Blood

Basic Attributes

Class

SERO

Type

Laboratory

First Released

Version 1.0h(2)

Last Updated

Version 2.73

Order vs. Observation

Observation

Common Test Rank

12881

Member of these Groups

Language Variants

Related Names

• ABS
• Aby
• Antby
• Anti
• Antibodies
• Antibody
• Autoantibodies
• Autoantibody
• Dilution factor
• Dilution Factor (Titer)
• Ganglioside monosialo
• GM1 Gangl
• Immune globulin M
• Immunoglobulin M
• Monosialoganglioside
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Serology
• Serum
• SR
• Titer
• Titered
• Titre
• Ttr

Example Units

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LOINC Copyright

Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.