6926-0
Ganglioside GM1 IgM Ab [Titer] in Serum
Active
Part Descriptions
LP36423-9 Ganglioside GM1
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. [PMID: 21214559]
Source: Regenstrief LOINC, PMID: 2121455
LP222219-0 Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Ganglioside GM1 Ab.IgM
- Property
- Titr
- Time
- Pt
- System
- Ser
- Scale
- Qn
- Method
Additional Names
- Short Name
- GM1 Gangl IgM Titr Ser
- Display Name
- Ganglioside GM1 IgM (S) [Titer]
- Consumer Name Alpha
- Ganglioside GM1 IgM antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 1.0h(2)
- Last Updated
- Version 2.73
- Order vs. Observation
- Observation
- Common Test Rank
- 12881
Member of these Groups
LOINC Group | Group Name |
---|---|
LG17145-0 | Ganglioside GM1 Ab.IgM| |
Language Variants
Tag | Language | Translation |
---|---|---|
zh-CN | Chinese (China) | 神经节苷脂 GM1 抗体.IgM: Synonyms: |
es-AR | Spanish (Argentina) | [anticuerpo anti - ] monosialogangliósido GM1 [Ac].IgM [Inmunoglobulina M]: |
fr-CA | French (Canada) | Ganglioside GM1 , IgM: |
et-EE | Estonian (Estonia) | Gangliosiid GM1 antikehad.IgM: Synonyms: |
pt-BR | Portuguese (Brazil) | Monosialogangliosídeo GM1 Ac.IgM: Synonyms: |
es-ES | Spanish (Spain) | Gangliósido GM1 IgM: |
ko-KR | Korean (Korea, Republic Of) | Monosialoganglioside GM1 Antibody.immunoglobulin M: |
it-IT | Italian (Italy) | Ganglioside GM1 Ab.IgM: Synonyms: |
fr-FR | French (France) | Ganglioside GM1 anticorps IgM: |
tr-TR | Turkish (Turkey) | Gangliozid GM1 Ab.IgM: Synonyms: |
ru-RU | Russian (Russian Federation) | Ганглиозид GM1 Ат.IgM: Synonyms: |
nl-NL | Dutch (Netherlands) | ganglioside GM1 As.IgM: Synonyms: |
fr-BE | French (Belgium) | Ganglioside GM1 Anticorps. IgM: Synonyms: |
es-MX | Spanish (Mexico) | Gangliósido GM1 Ab.IgM: |
Example Units
Unit | Source |
---|---|
titer | REGENSTRIEF |
{titer} | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR®
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=6926-0
LOINC Copyright
Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright