LOINC
Version 2.67

69358-0HPV E6+E7 mRNA cells/cells [Presence] in Cervix by Flow cytometry (FC)Active

Term Description

This term was created for an assay that identifies cervical cells containing HPV E6 and E7 polycistronic mRNA using in situ hybridization with oligonucleotides specific for the mRNA transcripts. The cells remain intact, and following fixation and permeabilization, the probes enter the cells. The flow cytometer measures two things: 1. Quantification of E6 and E7 mRNA in each cell and 2. The percentage of cells over-expressing E6 and E7 mRNA. The test does not report the percentage quantity but an ordinal (positive, negative, indeterminant) based on the reported percentage. This test is similar to LOINC 69002-4, which is a target amplification nucleic acid probe test to detect E6+E7 mRNA.
Source: Regenstrief LOINC

Part Description

LP136531-3   Cells.HPV E6+E7 mRNA
Most human papilloma virus (HPV) genomes encode for eight major proteins, six "early" (E1, E2, E3, E4, E6, and E7) and two "late" (L1 and L2). The "early" are regulatory in function. E6 and E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.HPV E6+E7 mRNA/cells
Property
PrThr
Time
Pt
System
Cvx
Scale
Ord
Method
Flow cytometry

Additional Names

Short Name
HPV E6+E7 mRNA cells/cells Cvx Ql FC
Display Name
HPV E6+E7 mRNA cells/cells FC Ql (Cvx)

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.38
Last Updated
Version 2.61
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
细胞.人乳头状瘤病毒 E6+E7 mRNA/细胞:存在情况或阈值:时间点:子宫颈:序数型:流式细胞测量术
nl-NLDutch (NETHERLANDS)
cellen.HPV E6+E7 mRNA/cellen:aanwezigheid:moment:cervix:ordinaal:flowcytometrie
fr-FRFrench (FRANCE)
Cellules HPV E6+E7 ARNm /cellules:Présence/Seuil:Ponctuel:Col de l'utérus:Qualitatif:Cytométrie de flux
it-ITItalian (ITALY)
Cellule.HPV E6+E7 mRNA/cellule:PrThr:Pt:Cvx:Ord:Citometria a flusso
ru-RURussian (RUSSIAN FEDERATION)
Клетки.ВПЧ E6+E7 mRNA/клетки:PrThr:ТчкВрм:Шейка:Пор:Проточная цитометрия
es-ESSpanish (SPAIN)
Células.HPV E6+E7 ARNm/células:PrThr:Punto temporal:Cuello uterino:Ord:Citometria de flujo (FC)
tr-TRTurkish (TURKEY)
Hücreler.HPV E6+E7 mRNA/Hücreler:MevcEşik:Zmlı:Cvx:Srl:Akış sitometri

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=69358-0