LOINC
Version 2.67

70970-9Cryoglobulin [Presence] in Serum by Hypotonic dilutionActive

Term Description

Cryoglobulins are proteins in the blood that are soluble at 37 degrees Celsius but precipitate at lower temperatures. There are three classes of cryoglobulins that are differentiated by what type of protein precipitates. In type 1, the proteins involved are monoclonal immunoglobulins, usually IgM. Type 2 proteins include a mixture of monoclonal IgM and polyclonal IgG proteins. Type 3 may include polyclonal IgM and IgG cryoglobulins. In some cases, the proteins congeal rather than precipitate when observed in the laboratory. An additional process of hypotonically diluting the serum may be required in these instances in order to observe precipitation. [PMID: 3787096]
Source: Regenstrief LOINC, PMID: 3787096

Part Description

LP15516-5   Cryoglobulin
Serum cryoglobulins are immunoglobulins that, in vitro, precipitate at temperatures below 37°C and redissolve on rewarming.Cryoglobulins can be transient and without clinical implications or they can be a marker of significant disease. Monoclonal cryoglobulins, which are IgG, IgM, or IgA, or monoclonal free light chains, are usually associated with haematological disorders. Mixed cryoglobulins, which contain polyclonal immunoglobulins with or without a monoclonal component, are found in many infectious and systemic disorders. There is a significant association between essential mixed cryoglobulinaemia and hepatitis C virus infection (> 90%). [PMID: 11825916] Source: Regenstrief LOINC, PMID: 11825916

Fully-Specified Name

Component
Cryoglobulin
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
Hypotonic dilution

Additional Names

Short Name
Cryoglob Ser Ql Hypotonic dilution
Display Name
Cryoglobulin Hypotonic dilution Ql (S)

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
冷球蛋白:存在情况或阈值:时间点:血清:序数型:低渗稀释
nl-NLDutch (NETHERLANDS)
cryoglobuline:aanwezigheid:moment:serum:ordinaal:hypotonische verdunning
fr-FRFrench (FRANCE)
Cryoglobulines:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Dilution hypotonique
it-ITItalian (ITALY)
Crioglobulina:PrThr:Pt:Siero:Ord:Diluizione ipotonica
pt-BRPortuguese (BRAZIL)
es-ESSpanish (SPAIN)
Crioglobulina:PrThr:Punto temporal:Suero:Ord:Disolución hipotónica
tr-TRTurkish (TURKEY)
Kriyoglobulin:MevcEşik:Zmlı:Ser:Srl:Hipotonik dilüsyon

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=70970-9