LOINC
Version 2.67

74109-04-hydroxycoumarins [Presence] in Unspecified specimen by Screen methodActive

Term Description

Screening for 4-hydroxycoumarins, such as warfarin, difenacoum, bromadiolone, and coumatetralyl, is performed to detect intentional or accidental poisoning from rodenticides. The overall screen result may be reported as "positive" or "negative" based on individual results for 4-hydroxycoumarins (rodenticides) tested.
Source: Regenstrief LOINC

Part Description

LP173607-5   4-hydroxycoumarins
4-Hydroxycoumarins are a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin (chromen-2-one). The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. The synthetic drugs in the 4-hydroxycoumarin class are all noted primarily for their use as anticoagulants, though they can have several additional effects. The simplest synthetic molecule in the 4-hydroxycoumarin class is warfarin, in which the aromatic 3-position substituent is a simple phenyl group. So called "super-warfarins" or second-generation anticoagulants in this class, were developed as rodenticides for rodents that have developed warfarin resistance. The second generation agents have even larger lipid-soluble substituents at the 3-position (e.g. brodifacoum), a chemical change that causes their half life in the body to be greatly increased (sometimes to months). The antirodenticide chemicals are sometimes incorrectly referred to as "coumadins" rather than 4-hydroxycoumarins (Coumadin is a brandname for warfarin). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, 4-hydroxycoumarins

Fully-Specified Name

Component
4-hydroxycoumarins
Property
PrThr
Time
Pt
System
XXX
Scale
Ord
Method
Screen

Additional Names

Short Name
4OH-coumarins XXX Ql Scn
Display Name
4-hydroxycoumarins Screen Ql (Unsp spec)

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.46
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
4-羟基香豆素类:存在情况或阈值:时间点:XXX:序数型:毒理学筛查试验
nl-NLDutch (NETHERLANDS)
4-hydroxycoumarinen:aanwezigheid:moment:XXX:ordinaal:screening
fr-FRFrench (FRANCE)
4-hydroxycoumarines:Présence/Seuil:Ponctuel:Milieux divers:Qualitatif:Dépistage
it-ITItalian (ITALY)
4-idrossicumarina:PrThr:Pt:XXX:Ord:Screening
pt-BRPortuguese (BRAZIL)
ru-RURussian (RUSSIAN FEDERATION)
4-гидроксикумарины:PrThr:ТчкВрм:XXX:Пор:Скрининг
es-ESSpanish (SPAIN)
4-hidroxicumarina:PrThr:Punto temporal:XXX:Ord:Cribado toxicológico
tr-TRTurkish (TURKEY)
4-Hidroksikumarinler:MevcEşik:Zmlı:XXX:Srl:Tarama

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74109-0