74109-04-hydroxycoumarins [Presence] in Unspecified specimen by Screen methodActive
Screening for 4-hydroxycoumarins, such as warfarin, difenacoum, bromadiolone, and coumatetralyl, is performed to detect intentional or accidental poisoning from rodenticides. The overall screen result may be reported as "positive" or "negative" based on individual results for 4-hydroxycoumarins (rodenticides) tested.
Source: Regenstrief LOINC
4-Hydroxycoumarins are a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin (chromen-2-one). The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. The synthetic drugs in the 4-hydroxycoumarin class are all noted primarily for their use as anticoagulants, though they can have several additional effects. The simplest synthetic molecule in the 4-hydroxycoumarin class is warfarin, in which the aromatic 3-position substituent is a simple phenyl group. So called "super-warfarins" or second-generation anticoagulants in this class, were developed as rodenticides for rodents that have developed warfarin resistance. The second generation agents have even larger lipid-soluble substituents at the 3-position (e.g. brodifacoum), a chemical change that causes their half life in the body to be greatly increased (sometimes to months). The antirodenticide chemicals are sometimes incorrectly referred to as "coumadins" rather than 4-hydroxycoumarins (Coumadin is a brandname for warfarin). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, 4-hydroxycoumarins
- Short Name
- 4OH-coumarins XXX Ql Scn
- Display Name
- 4-hydroxycoumarins Screen Ql (Unsp spec)
- First Released
- Version 2.46
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
Example Answer List LL360-9
Source: Regenstrief Institute
|Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
Language Variants Get Info
- zh-CNChinese (CHINA)
存在情况或阈值: 时间点: XXX: 序数型: 毒理学筛查试验
- nl-NLDutch (NETHERLANDS)
aanwezigheid: moment: XXX: ordinaal: screening
- fr-FRFrench (FRANCE)
Présence/Seuil: Ponctuel: Milieux divers: Qualitatif: Dépistage
- it-ITItalian (ITALY)
PrThr: Pt: XXX: Ord: Screening
- pt-BRPortuguese (BRAZIL)
- ru-RURussian (RUSSIAN FEDERATION)
PrThr: ТчкВрм: XXX: Пор: Скрининг
- es-ESSpanish (SPAIN)
PrThr: Punto temporal: XXX: Ord: Cribado toxicológico
- tr-TRTurkish (TURKEY)
MevcEşik: Zmlı: XXX: Srl: Tarama
LOINC FHIR® API Example - CodeSystem Request Get Info
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