LOINC
Version 2.67

74121-5Perforin Ag [Presence] in Tissue by Immune stainActive

Part Description

LP33048-7   Perforin
Perforin-1 is a protein that in humans is encoded by the PRF1 gene.

Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood.

Perforin is a cytolytic protein found in the granules of CD8 T-cells and NK cells. Upon degranulation, perforin inserts itself into the target cell's plasma membrane, forming a pore. The lytic membrane-inserting part of perforin is the MACPF domain. This region shares homology with cholesterol-dependent cytolysins from Gram-positive bacteria.

Although purified perforin is sufficient to lyse cells at high doses, the biology of perforin itself does not explain the ability of CD8 T-cells and NK cells to induce apoptosis in target cells. This induction of apoptosis may require at least one other granule protein, granzyme B. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component
Perforin Ag
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
Immune stain

Additional Names

Short Name
Perforin Ag Tiss Ql ImStn
Display Name
Perforin Ag Immune stain Ql (Tiss)

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.46
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
穿孔素 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
nl-NLDutch (NETHERLANDS)
perforine Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
et-EEEstonian (ESTONIA)
Perforiin antigeen:PrThr:Pt:Tis:Ord:Immuunvärv
fr-BEFrench (BELGIUM)
Perforine Ag:PrThr:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
fr-CAFrench (CANADA)
Perforine , Ag:Présence-Seuil:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
fr-FRFrench (FRANCE)
Perforine antigène:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
it-ITItalian (ITALY)
Perforina , Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
pt-BRPortuguese (BRAZIL)
ru-RURussian (RUSSIAN FEDERATION)
Перфорин Аг:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска
es-ESSpanish (SPAIN)
Perforina Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
tr-TRTurkish (TURKEY)
Perforin Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74121-5