LOINC
Version 2.73

74168-6Barbiturates [Mass/volume] in Saliva (oral fluid) by Screen methodActive

Part Descriptions

LP14546-3   Barbiturates
Barbiturates are CNS depressants that primarily act on gamma-aminobutyric acid (GABA) and GABA A receptors. When GABA binds to GABA A, chloride channels open and allow the influx of chloride ions, which decrease the membrane potential and inhibit the neuron's action potential. They are used as sedatives, hypnotics, anesthetics, and anticonvulsants. Prolonged use can lead to physical tolerance and dependence, which has caused a significant decrease in their use over time. However, certain uses are still common, such as phenobarbital for refractory seizure disorders, butalbital for analgesia, and thiopental for anesthesia. [PMID:25824249] Source: Regenstrief LOINC

LP7565-7   Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin.[PMID:17268583] Source: Regenstrief LOINC

LP262420-5   Saliva DRUG/TOX
Oral fluid (or saliva) is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. The test procedures that use oral fluid for drug screening are usually similar to those for other specimens but adapted for oral fluid. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Drugs present in oral fluid are often the parent drug rather than a metabolite and tests kits reflect those differences. Concentrations of cocaine, amphetamines and some opioids in oral fluid are either similar or higher than concentrations in plasma. The concentration of tetrahydrocannabinol (THC) in oral fluid is similar to that of plasma, though in cases where recent ingestion has occurred, levels may be higher due to the significant local absorption in the oral cavity. Confirmatory testing on oral fluid using liquid chromatography-mass spectrometry (LC-MS) is highly sensitive and specific even on relatively small sample sizes. An increased understanding of pharmacokinetics in oral fluid has flourished inover the last ten years has allowed the correlation of . As a result, the concentrations of various drugs in oral fluid have been correlated to blood concentrations and the effects they have on the individual.[PMID:17268583] Source: Regenstrief LOINC

Fully-Specified Name

Component
Barbiturates
Property
MCnc
Time
Pt
System
Saliva
Scale
Qn
Method
Screen

Additional Names

Short Name
Barbiturates Sal Scn-mCnc
Display Name
Barbiturates Screen (Sal) [Mass/Vol]
Consumer Name Alpha
Barbiturates, Saliva

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.46
Last Updated
Version 2.46
Order vs. Observation
Both

Member of these Groups

LG50143-3 Barbiturates|ANYProp|ANYTm|ANYSys|ANYMeth

Language Variants Get Info

zh-CNChinese (China)
巴比妥类药物:质量浓度:时间点:唾液:定量型:毒理学筛查试验
nl-NLDutch (Netherlands)
barbituraten:massa/volume:moment:speeksel:kwantitatief:screening
fr-BEFrench (Belgium)
Barbituriques:Concentration de masse:Temps ponctuel:Salivaire:Quantitatif:Dépistage
fr-CAFrench (Canada)
Barbituriques:Concentration de masse:Temps ponctuel:Salivaire:Quantitatif:Dépistage
fr-FRFrench (France)
Barbituriques:Masse/Volume:Ponctuel:Salive:Numérique:Dépistage
it-ITItalian (Italy)
Barbiturici:MCnc:Pt:Saliva:Qn:Screening
pt-BRPortuguese (Brazil)
Barbituratos::Pt:Saliva:Qn:Triagem
ru-RURussian (Russian Federation)
Барбитураты:МассКонц:ТчкВрм:Слюна:Колич:Скрининг
es-MXSpanish (Mexico)
Barbitúricos:Concentración de masa:Punto temporal:Saliva:Cuantitativo:Pantalla de toxicología
es-ESSpanish (Spain)
Barbituratos:Concentración de masa:Punto temporal:Saliva:Qn:Cribado toxicológico
tr-TRTurkish (Turkey)
Barbitüratlar:KütlKons:Zmlı:Tükürük:Kant:Tarama

Example Units

Unit Source
ng/mL Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74168-6