LOINC
Version 2.67

74821-0Chikungunya virus Ab [Presence] in Serum by Hemagglutination inhibitionActive

Part Descriptions

LP21132-3   Chikungunya virus
A species of ALPHAVIRUS causing an acute dengue-like fever. Source: National Library of Medicine, MeSH 2006

LP21132-3   Chikungunya virus
Chikungunya virus (CHIKV) belongs to the mosquito-borne alphavirus genus, in the family Togaviridae, and was first observed in epidemic form in Africa. Serologically, CHIKV belongs to the Semliki Forest (SF) subgroup of alphaviruses. Infection in humans is characterized by rash, high fever and, its hallmark feature, severe arthritis that can persist for years. CHIKV is a small, spherical, enveloped, positive-strand RNA virus. The virion consists of an envelope and a nucleocapsid. The envelope glycoproteins of alphaviruses are the distinguishing factors for testing. The CHIKV genome encodes for two polyproteins; the non-structural polyprotein consisting of four proteins (nsP1, nsP2, nsP3 and nsP4) and the structural polyprotein consisting of five proteins (Capsid, E3, E2, 6K and E1). CHIKV has spikes on the virion surface that are each formed by three E1-E2 heterodimers, where the E1 glycoproteins mediate fusion and E2 glycoproteins interact with the host receptor. [PMID: 20111039]
CHIKV can be detected between the first and fourth day of infection (the acute phase) using PCR or virus cultivation, and virus-specific IgM and IgG antibodies can be detected during the 8th to the 10th day of infection. Antibody investigation should be performed using serum samples from the acute and convalescent stage. Source: Regenstrief LOINC

LP6304-2   HAI
The hemagglutination-inhibition assay (HAI) can be used to identify subtypes of hemagglutinin producing viruses, such as Influenza. HAI can also be used to identify the subtype-specificity of antibodies against the virus. Normally, Influenza's hemagglutinin glycoprotein binds to receptors on the surface of red blood cells, causing them to agglutinate. If antibodies specific to the virus are present in the patient sample, they will bind to the virus, which prevents the virus from binding to the red blood cells and therefore prevents agglutination. To determine which subtype of virus is present, a viral isolate is tested against a series of antibodies with known subtype specificities. Whichever antibody inhibits red cell agglutination identifies the viral subtype. Similarly, antibody specificity is identified by testing the patient sample against known virus subtypes. [PMID: 24899416] Source: Regenstrief LOINC

Fully-Specified Name

Component
Chikungunya virus Ab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
HAI

Additional Names

Short Name
CHIKV Ab Ser Ql HAI
Display Name
CHIKV Ab HAI Ql (S)

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.48
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
基孔肯亚病毒 抗体:存在情况或阈值:时间点:血清:序数型:红细胞凝集抑制试验法
nl-NLDutch (NETHERLANDS)
Chikungunya-virus As:aanwezigheid:moment:serum:ordinaal:hemagglutinatieremming
fr-BEFrench (BELGIUM)
Virus Chikungunya Ac:PrThr:Temps ponctuel:Sérum:Ordinal:Inhibition de l'hémagglutination
fr-CAFrench (CANADA)
Virus Chikungunya , Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Inhibition de l'hémagglutination
fr-FRFrench (FRANCE)
Chikungunya virus Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Hémagglutination indirecte
it-ITItalian (ITALY)
Chikungunya virus , Ab:PrThr:Pt:Siero:Ord:HAI
pt-BRPortuguese (BRAZIL)
Chikungunya vírus Ac:Limiar:Pt:Soro:Ord:Hemaglutinação indireta
es-ESSpanish (SPAIN)
Virus Chikungunya Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inhibición de la Hemaglutinación
tr-TRTurkish (TURKEY)
Chikungunya virus Ab:MevcEşik:Zmlı:Ser:Srl:HAI

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74821-0