LOINC
Version 2.67

75694-0Human papilloma virus 18+45 E6+E7 mRNA [Presence] in Cervix by NAA with probe detectionActive

Term Description

Detects E6/E7 viral messenger RNA (mRNA) of human papillomavirus (HPV) types 18 and 45 in cervical specimens from women with positive HPV assay results. E6/E7 oncogenes must be expressed for malignant transformation. For women 21-years and older with atypical squamous cells of undetermined significance (ASC-US) cervical cytology results, and HPV positive assay results, this assay can be used to assess the presence or absence of high-risk HPV genotypes 18, and/or 45. For women 30-years and older, the HPV 18, and/or 45 genotype assay can be used to test samples from women with HPV assay positive results, along with cervical cytology results. This assay has not been evaluated for HPV vaccinated patients or in cases of suspected abuse. It does not differentiate HPV 18 and HPV 45. This term was created for, but not limited in use to, the Aptima HPV 16 18/45 genotype assay which uses target capture, target amplification by transcription-mediated amplification and detection of the amplification products by hybridization protection. To report results for HPV 16 see Human papilloma virus 16 E6+E7 mRNA [Presence] in Cervix by Probe and signal amplification method [LOINC: 82456-5].
Source: Regenstrief LOINC

Part Description

LP185927-3   Human papilloma virus 18+45 E6+E7 mRNA
HPV type 16 and 18 are the most common carcinogenic HPV types. HPV type 16 is detected in about 50% of invasive cervical cancers worldwide and is associated with a higher risk of a severe cervical intraepithelial neoplasia (CIN 3). HPV type 16 is one of the greatest risks for HPV persistence along with increasing age, smoking, immunosuppression, inflammation, hormones, and genetic factors. HPV type 18 is detected in 10% to 20% of invasive cervical cancers and more commonly found in adenocarcinomas compared to squamous-cell cervical carcinomas. [PMID: 19061814] Source: Regenstrief LOINC, PMID: 19061814

Fully-Specified Name

Component
Human papilloma virus 18+45 E6+E7 mRNA
Property
PrThr
Time
Pt
System
Cvx
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
HPV18+45 E6+E7 mRNA Cvx Ql NAA+probe
Display Name
HPV 18+45 E6+E7 mRNA NAA+probe Ql (Cvx)

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.50
Last Updated
Version 2.63
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016. Changed the method from 'Probe.amp.sig' to 'Probe.amp.tar' to correctly reflex the HPA procedure.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Member of these Panels

LOINC Long Common Name
90766-7 HEDIS 2019 Value Sets
94137-7 HEDIS 2020 Value Sets
82457-3 Human papilloma virus 16 and 18+45 E6+E7 mRNA panel - Cervix by NAA with probe detection

Language Variants Get Info

zh-CNChinese (CHINA)
人乳头瘤病毒 18+45 E6+E7 mRNA:存在情况或阈值:时间点:子宫颈:序数型:探针法.基因扩增.靶向
nl-NLDutch (NETHERLANDS)
Humaan papilloma virus 18+45 E6+E7 mRNA:aanwezigheid:moment:cervix:ordinaal:moleculaire techniek (PCR)
fr-FRFrench (FRANCE)
Papillomavirus humain 18+45 ARNm E6+E7:Présence/Seuil:Ponctuel:Col de l'utérus:Qualitatif:PCR amplification de cible
it-ITItalian (ITALY)
Papilloma virus umano 18+45 E6+E7 mRNA:PrThr:Pt:Cvx:Ord:Sonda.amp.tar
es-ESSpanish (SPAIN)
Papilomavirus humano 18+45 E6+E7 ARNm:PrThr:Punto temporal:Cuello uterino:Ord:Sonda con amplificación dirigida
tr-TRTurkish (TURKEY)
Human papilloma virüs 18+45 E6+E7 mRNA:MevcEşik:Zmlı:Cvx:Srl:Prob.amf.hdf

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=75694-0