Version 2.67

77354-9Noninvasive colorectal cancer DNA and occult blood screening [Presence] in StoolActive

Term Description

This term was created for, but is not limited in use to, Exact Sciences' Cologuard DNA screening test for colorectal cancer. The Cologuard algorithm includes two laboratory procedures performed on a single stool specimen: 1) detection and quantification of fecal occult blood using ELISA; and 2) detection of multiple genetic biomarkers (NDRG4 and BMP3 methylation targets, seven KRAS point mutations, and beta actin as a proxy for the total amount of human DNA in each sample) using magnetic bead based oligonucleotide hybrid capture to isolate the biomarkers followed by quantitative real-time target and signal amplification. The occult blood and genetic biomarker results are subsequently entered into a logistic regression model, and the results from this model are used to calculate a composite score from which the final binary result (positive, negative) is determined. [PMID: 24645800]
Source: Regenstrief LOINC

Fully-Specified Name

Noninvasive colorectal cancer DNA+occult blood screening

Additional Names

Short Name
Noninv colon ca DNA+occ bld scrn Stl Ql
Display Name
Noninvasive colorectal cancer DNA and occult blood screening Ql (Stl)

Basic Attributes

First Released
Version 2.52
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation

Example Answer List LL3293-9

Source: Exact Sciences Laboratories

Answer Code Score Answer ID
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Sample could not be processed LA22772-0
No result obtained LA22773-8

Member of these Panels

LOINC Long Common Name
82955-6 HEDIS 2017 Value Sets
87625-0 HEDIS 2018 Value Sets
90766-7 HEDIS 2019 Value Sets
94137-7 HEDIS 2020 Value Sets

Language Variants Get Info

zh-CNChinese (CHINA)
无创性结直肠癌 DNA+潜血筛查:存在情况或阈值:时间点:大便:序数型:
fr-FRFrench (FRANCE)
Noninvasive colorectal cancer DNA+occult blood screening:PrThr:Pt:Stool:Ord:
it-ITItalian (ITALY)
Screening non invasivo DNA+sangue occulto tumore colorettale:PrThr:Pt:Feci:Ord:
es-ESSpanish (SPAIN)
Screening no invasivo de cancer colorectal ADN+sangre oculta:PrThr:Punto temporal:Heces:Ord:
tr-TRTurkish (TURKEY)
Noninvaziv kolorektal kanser DNA+gaitada gizli kan tarama:MevcEşik:Zmlı:Dışkı:Srl:

LOINC FHIR® API Example - CodeSystem Request Get Info