Version 2.73

78894-3Liver fibrosis score in Serum or Plasma Calculated by HepaScoreActive

Term Description

This term was created for the HepaScore liver fibrosis test, which is a marker of liver fibrosis in patients with hepatitis C infection. The score ranges from 0 to 1 and is calculated based on four lab tests (GGT, bilirubin, alpha-2-macroglobulin, and hyaluronic acid) plus the patient's age and gender. The HepaScore is reported with a central cut-off of 0.50, with a value ≥ 0.50 indicating that significant liver fibrosis is present (positive predictive value 88%) and a value < 0.50 indicating that advanced fibrosis is absent (negative predictive value 95%) for patients with hepatitis C infection. The HepaScore logistic regression model is as follows: y = exp[-4.185818 - (0.0249 x age) + (0.7464 x sex) + (1.0039 x α2-macroglobulin) + (0.0302 x hyaluronic acid) + (0.0691 x bilirubin) - (0.0012 x GGT)]
with age provided in years, male sex = 1, female sex = 0, α2-macroglobulin in g/L, hyaluronate in μg/L, bilirubin in μmol/L, and GGT in U/L. The score itself is calculated as y/(1 +y). [PMID:16055434]
Source: Regenstrief LOINC

Part Description

LP193274-0   Liver fibrosis score
A liver fibrosis score is a noninvasive method used to determine the presence and degree of liver fibrosis in a patient based on a variety of different parameters (e.g., lab tests, age, and gender) depending on the method used.[PMID:21254180]. Different methods used to calculate a patient's liver fibrosis score include the Enhanced Liver Fibrosis (ELF) test, nonalcoholic fatty liver disease (NAFLD) fibrosis score, HepaScore, FibroMeter, and FibroSURE. Source: Regenstrief LOINC

Fully-Specified Name

Liver fibrosis score

Additional Names

Short Name
Liver fibr score SerPl Calc HepaScore
Display Name
Liver fibrosis score Calculated by HepaScore [Score]
Consumer Name Alpha
Liver fibrosis score, Blood

Basic Attributes

First Released
Version 2.54
Last Updated
Version 2.54
Order vs. Observation

Formula (Readable)

HepaScore = y/(1+y), where y = exp[-4.185818 - (0.0249 x age) + (0.7464 x sex) + (1.0039 x α2-macroglobulin) + (0.0302 x hyaluronic acid) + (0.0691 x bilirubin) - (0.0012 x GGT)]

Member of these Panels

LOINC Long Common Name
78698-8 Liver fibrosis score panel - Serum or Plasma Calculated by HepaScore

Member of these Groups

LG19496-5 Liver fibrosis score|Score|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
fr-FRFrench (France)
Score de fibrose du foie:Score:Ponctuel:Sérum/Plasma:Numérique:Calcul par Hepascore
it-ITItalian (Italy)
Fibrosi epatica, punteggio:Punteggio:Pt:Siero/Plasma:Qn:Calcolato.HepaScore
es-MXSpanish (Mexico)
Puntuación de fibrosis hepática:Puntaje:Punto temporal:Suero o Plasma:Cuantitativo:Calculado por HepaScore
es-ESSpanish (Spain)
Puntuación fibrosis hepática:Puntuación:Punto temporal:Suero o Plasma:Qn:Calculado por HepaScore

Example Units

Unit Source
{score} Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info