Version 2.70

78993-3Prolactin isoforms panel - Serum or PlasmaActive

Term Description

The prolactin isoforms panel includes individual tests for monomeric, dimeric, and macroprolactin, as well as fraction terms for each isomer and an interpretation based on all of the results. Monomeric prolactin is the most common form of circulating prolactin. The dimeric form ("big-prolactin") has a molecular weight of ~50 kD, and polymeric form ("big-big prolactin") has a molecular weight of ~ 150 kD). Big-big prolactin, known as macroprolactin, and big prolactin are formed in the circulation after secretion of prolactin from the pituitary. They have a longer half-life than monomeric prolactin and are not biologically active. However, typical prolactin assays do not differentiate between the different forms of prolactin, and the presence of big and big-big prolactin can lead to a false diagnosis of hyperprolactinemia. Methods such as PEG precipitation can separate macroprolactin and big prolactin from monomeric prolactin in order to obtain a more accurate measurement of biologically active prolactin, and chromatography can be used to further characterize the isoforms if necessary. [PMCID: PMC3719302]
Source: Regenstrief LOINC

Panel Hierarchy
Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
78993-3 Prolactin isoforms panel - Serum or Plasma
Indent15081-3 Prolactin [Units/volume] in Serum or Plasma m[IU]/L
Indent78994-1 Prolactin monomeric [Units/volume] in Serum or Plasma [arb'U]/L
Indent78995-8 Prolactin monomeric/Prolactin in Serum or Plasma %
Indent78985-9 Prolactin.dimeric [Units/volume] in Serum or Plasma [arb'U]/L
Indent78986-7 Prolactin.dimeric/Prolactin in Serum or Plasma %
Indent74953-1 Macroprolactin [Units/volume] in Serum or Plasma [arb'U]/L
Indent78984-2 Macroprolactin/Prolactin in Serum or Plasma %
Indent79398-4 Prolactin isoforms pattern [Interpretation] in Serum or Plasma Narrative

Fully-Specified Name

Prolactin isoforms panel

Additional Names

Short Name
Prolactin isoforms Pnl SerPl
Display Name
Prolactin isoforms panel
Consumer Name Alpha
Prolactin isoforms panel, Blood

Basic Attributes

First Released
Version 2.54
Last Updated
Version 2.54
Order vs. Observation
Panel Type

Language Variants Get Info

zh-CNChinese (China)
nl-NLDutch (Netherlands)
prolactine isovormen panel:-:moment:serum of plasma:-:
fr-FRFrench (France)
Prolactines isoformes panel:-:Ponctuel:Sérum/Plasma:-:
it-ITItalian (Italy)
Isoforme della prolattina, panel:-:Pt:Siero/Plasma:-:
es-ESSpanish (Spain)
Panel isoformas prolactina:Propiedades mixtas (sólo paneles):Punto temporal:Suero o Plasma:-:

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