LOINC
Version 2.72

79387-7Escherichia coli Stx2 toxin stx2 gene [Presence] in Stool by NAA with probe detectionActive

Term Description

This term was created for, but is not limited in use to, Nanosphere's Verigene Enteric Pathogens Nucleic Acid Test, which is intended for the detection and identification of common pathogenic enteric bacteria, viruses, and genetic virulence markers in stool specimens from individuals with signs and symptoms of gastrointestinal infection.
Source: Regenstrief LOINC

Part Description

LP262477-5   Escherichia coli Stx2 toxin stx2 gene
The Stx1 toxin A subunit is encoded by the stx1 gene [www.uniprot.org/uniprot/ ?query=stx1+escherichia+coli&sort=score] and the Stx2 toxin A subunit is encoded by the stx2 gene.[UniProt:K0JD26] Stx1a and Stx2a are produced by some serogroups of Escherichia coli (also known as Vero toxins and previously referred to as Shiga-like toxins) are two cytotoxins that cause hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). The two toxins produce similar symptoms, but are immunologically unique. Both toxins are composed of a single copy of subunit A and five copies of subunit B. Stx1a and Stx1b induce host cell apoptosis by removing an adenine residue from the 28S rRNA of the 60S ribosome, with RNA-N-glycosidase activity provided by subunit A. The five B subunits bind to the host cell receptor present on endothelial cells.[PMID:25530917] Shigella toxin-producing Escherichia coli (STEC) has become a serious food-borne pathogen. Outbreaks of STEC have been associated with the consumption of pork products resulting in HC and HUS. STEC in swine has been demonstrated to cause edema disease. Epidemiological studies throughout the world have proven that STEC can be harbored and shed by domestic swine.[PMID:24397985] Source: Regenstrief LOINC

Fully-Specified Name

Component
Escherichia coli Stx2 toxin stx2 gene
Property
PrThr
Time
Pt
System
Stool
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
EC stx2 gene Stl Ql NAA+probe
Display Name
E. coli stx2 gene NAA+probe Ql (Stl)
Consumer Name Alpha
Escherichia coli stx2 toxin stx2 gene, Stool

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.64
Change Reason
Changed Component from "Bacterial shiga-like toxin 2 (stx2) gene" to "Escherichia coli shiga-like toxin 2 (stx2) gene" since stx1 is only produced by E.coli.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Updated Component from "Escherichia coli shiga-like toxin 2 (stx2) gene" based on the current E. coli nomenclature and LOINC model.
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
81659-5 Escherichia coli Stx1 and Stx2 toxin stx1 and stx2 genes panel - Stool by NAA with probe detection
79381-0 Gastrointestinal pathogens panel - Stool by NAA with probe detection

Language Variants Get Info

zh-CNChinese (China)
大肠埃希菌 Stx2 毒素 stx2 基因:存在情况或阈值:时间点:大便:序数型:探针法.基因扩增.靶向
nl-NLDutch (Netherlands)
Escherichia coli Stx2-toxine stx2-gen:aanwezigheid:moment:feces:ordinaal:moleculaire techniek (PCR)
fr-FRFrench (France)
Escherichia coli toxine stx2 gène:Présence/Seuil:Ponctuel:Selles:Qualitatif:PCR amplification de cible
de-DEGerman (Germany)
Escherichia coli Stx2 Toxin stx2-Gen:Nachweis oder Schwellenwert:Zeitpunkt:Stuhl:Ordinal:Zielfragmentamplifikation mit Sondendetektion
it-ITItalian (Italy)
Escherichia coli tossina Stx2, gene stx2:PrThr:Pt:Feci:Ord:Sonda.amp.tar
es-MXSpanish (Mexico)
Escherichia coli Toxina Stx2 Gen stx2:Presencia o umbral:Punto temporal:Heces:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
es-ESSpanish (Spain)
Gen stx2 Escherichia coli:PrThr:Punto temporal:Heces:Ord:Sonda con amplificación dirigida

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79387-7