Version 2.72

80351-0Escherichia coli enterotoxigenic ltA+st1a+st1b genes [Presence] in Stool by NAA with non-probe detectionActive

Term Description

This assay detects the presence of one or more of the Escherichia coli enterotoxigenic ltA, st1a and st1b toxins using PCR and melt curve analysis. The assay does not distinguish between the three toxins. This term was created for, but is not limited in use to, BioFire's FilmArray Gastrointestinal panel, which is intended for the detection and identification of nucleic acids from multiple bacteria, viruses, and parasites directly from stool samples from individuals with signs and/or symptoms of gastrointestinal infection.
Source: Regenstrief LOINC

Part Description

LP200472-1   Escherichia coli enterotoxigenic ltA+st1a+st1b genes
Enterotoxigenic Escherichia coli (ETEC) produces a heat-labile (LT) and a heat-stable (ST) enterotoxin, both of which cause severe diarrhea in both humans and animals. ST is an extracellular toxin which is comprised of a methanol-soluble (STa) toxin and a methanol-insoluble (STb) toxin. The sta gene encodes the STa toxin and the stb gene encodes the STb toxin. [UniProt:Q70Q79]; [UniProt:Q70Q73] STa combines to its enterocyte receptor, guanylate cyclase, which causes intestinal secretion and diarrhea.[PMID:8528070] The STb enterocyte receptor is the protein sulfatide. After STb binds to sulfatide, it is engulfed by the enterocyte. It then activates the pertussis toxin-sensitive G protein which opens the ligand-gated calcium ion channel, allowing an influx of calcium ions. A subsequent secretion of chloride ions, stimulation of arachidonic acid release, and production of prostaglandin E2 and 5-dyroxytryptamine leads to an efflux of water, bicarbonate ions, sodium ions, and chloride ions into the intestinal space, all of which leads to watery diarrhea.[PMID:23716609] Source: Regenstrief LOINC

Fully-Specified Name

Escherichia coli enterotoxigenic ltA+st1a+st1b genes

Additional Names

Short Name
ETEC ltA+st1a+st1b tox St NAA+non-probe
Display Name
E. coli enterotoxigenic ltA+st1a+st1b genes NAA+non-probe Ql (Stl)
Consumer Name Alpha
Escherichia coli enterotoxigenic ltA+st1a+st1b genes, Stool

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

First Released
Version 2.54
Last Updated
Version 2.63
Change Reason
Changed component name to clarify that this assay detects the toxin genes (vs. protein). Changed Method from "Melt.amp.tar" to "Non-probe.amp.tar", which includes other non-probe based detection methods while still distinguishing from probe-based methods.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation

Member of these Panels

LOINC Long Common Name
82195-9 Gastrointestinal pathogens DNA and RNA panel - Stool by NAA with non-probe detection

Language Variants Get Info

zh-CNChinese (China)
大肠埃希菌肠产毒素型 ltA+st1a+st1b 基因:存在情况或阈值:时间点:大便:序数型:非探针法.基因扩增.靶向
fr-FRFrench (France)
Escherichia coli entérotoxinogène ltA+st1a+st1b gènes:Présence/Seuil:Ponctuel:Selles:Qualitatif:Non-PCR amplification de cible
it-ITItalian (Italy)
Escherichia coli enterotossigeni geni ItA+st1a+st1b:PrThr:Pt:Feci:Ord:Non-sonda.amp.tar
es-MXSpanish (Mexico)
Genes enterotoxigénicos ltA + st1a + st1b de Escherichia coli:Presencia o umbral:Punto temporal:Heces:Ordinal:Amplificación de ácidos nucleicos con detección sin sonda
es-ESSpanish (Spain)
toxinas ltA+st1a+st1b de Escherichia coli enterotoxigénica:PrThr:Punto temporal:Heces:Ord:Amplificación del objetivo no basado en sonda

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