80588-7Influenza virus A M gene [Presence] in Nasopharynx by NAA with probe detectionActive
Term Description
Detection of targeted nucleic acid sequences in the Influenza A matrix protein (M) gene RNA by PCR-based methods. This term was created for, but not limited in use to, the Verigene® Respiratory Pathogens Flex Nucleic Acid Test (RP Flex), a multiplexed, qualitative test for the detection and identification of multiple viral and bacterial genetic virulence markers from nasopharyngeal swab specimens.
Source: Regenstrief LOINC
Part Descriptions
LP206581-3 Influenza virus A M gene
The matrix protein gene of influenza virus A encodes two proteins: a matrix protein (M1) and an ion channel protein (M2). M1 plays a critical role in virus structure and replication by building connections between the viral lipid membrane and ribonucleoprotein (RNP) core. M1 also binds to RNPs in the nucleus, inhibiting viral transcription. The ion channel (M2) protein spans the lipid bilayer.
Source: Regenstrief LOINC
LP206581-3 Influenza virus A M gene
The influenza virus A (FLUVA) genome is composed of eight gene segments (PB2, PB1, PA, HA, NP, NA, M, NS1) that code for 11 proteins. Two of the genes, hemagglutinin (HA) and neuraminidase (NA), determine the structure of the two primary surface proteins of influenza viruses. The HA and NA gene sequences are used to determine the Influenza virus subtype. Currently there are 16 subtypes of HA and 9 subtypes of NA known, but only H 1, 2 and 3, and N 1 and 2 are commonly found in humans.[PMID:17458769] The M gene segment, which encodes two matrix proteins (M1 and M2), may also be used as a target in PCR-based assays for detection of FLUVA in various specimens.
Source: Regenstrief LOINC
LP206581-3 Influenza virus A M gene
The influenza A virus (FLUAV) is a common respiratory virus that infects humans as well as birds, horses, seals, dogs, and pigs. There are eight gene segments that make up the negative single-stranded RNA of the FLUAV. The gene segments are known as PB1, PB2, PA, NP, HA, NA, M, and NS. The M gene is the seventh segment and encodes the M1 (matrix protein) and M2 (membrane) proteins. [https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-6-67] The M1 protein is located beneath the lipid membrane and functions to give support and strength to the viral envelope. The M2 transmembrane protein is an ion channel that assists to uncover the virus once it is inside the host cell. M1 and NP proteins together determine whether the influenza virus is type A, B, or C. M1 brings viral constituents together to the assembly location, playing important roles in the creation of viral particles and in the budding process.[http://www.clinlabnavigator.com/influenza-virus-subtypes.html]
Source: Regenstrief LOINC, A blood group
Fully-Specified Name
- Component
- Influenza virus A M gene
- Property
- PrThr
- Time
- Pt
- System
- Nph
- Scale
- Ord
- Method
- Probe.amp.tar
Additional Names
- Short Name
- FLUAV M gene Nph Ql NAA+probe
- Display Name
- FLUAV M gene NAA+probe Ql (Nph)
- Consumer Name Alpha
- Influenza A M gene, Nasopharynx
Example Answer List LL744-4
Source: Regenstrief Institute
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Detected | LA11882-0 | ||
| Not detected | LA11883-8 |
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.56
- Last Updated
- Version 2.63
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 78922-2 | Respiratory pathogens DNA and RNA panel - Nasopharynx by NAA with probe detection |
Member of these Groups
| LG32757-3 | Influenza virus |
Language Variants Get Info
- zh-CNChinese (China)
- 流感病毒 A 型 M 基因:
存在情况或阈值: 时间点: 鼻咽: 序数型: 探针法.基因扩增.靶向 - nl-NLDutch (Netherlands)
- Influenzavirus A M-gen:
aanwezigheid: moment: neusholte: ordinaal: moleculaire techniek (PCR) - fr-FRFrench (France)
- Influenza virus A gène M:
Présence/Seuil: Ponctuel: Nasopharynx: Qualitatif: PCR amplification de cible - it-ITItalian (Italy)
- Virus Influenza A gene M:
PrThr: Pt: Nph: Ord: Sonda.amp.tar - es-MXSpanish (Mexico)
- Gen A M del virus de la influenza:
Presencia o umbral: Punto temporal: Nasofaringe: Ordinal: Amplificación de ácidos nucleicos con detección de sonda - es-ESSpanish (Spain)
- Genes A+B Metapneumovirus humano:
PrThr: Punto temporal: Nasofaringe: Ord: Sonda con amplificación dirigida
LOINC FHIR® API Example - CodeSystem Request Get Info
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=80588-7
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