Version 2.73

80685-1Clostridioides difficile toxin A+B tcdA+tcdB genes [Presence] in Stool by NAA with probe detectionActive

Term Description

Qualitative detection of nucleic acid sequences in the Clostridium difficile toxin A (tcdA) and B (tcdB) genes in stool specimens by real-time PCR methods. This assay does not differentiate between C. difficile toxin A and B genes. This term was created for, but not limited in use to, the submitter's test kit, xTAG® Gastrointestinal Pathogen Panel (GPP).
Source: Regenstrief LOINC

Part Description

LP204848-8   Clostridioides difficile toxin A+B tcdA+tcdB genes
Clostridium difficile toxin's A and B are encoded by the tcdA and tcdB genes, respectively.[PMID:20664812] They share similar molecular characteristics with comparable sizes (308 kD for tcdA and 269 for tcdB) and 63% homology in their amino acid sequences.[PMID:9312171] TcdA and tcdB are expressed in response to environmental stresses, such as antibiotics.[ PMID 15831824] Nucleic acid sequences within these genes are targeted to confirm the presence of C. difficile toxins and diagnose the cause of diarrhea, abdominal pain, fever, nausea and other toxin-producing symptoms. Source: Regenstrief LOINC

Fully-Specified Name

Clostridioides difficile toxin A+B tcdA+tcdB genes

Additional Names

Short Name
C dif tox tcdA+tcdB Stl Ql NAA+probe
Display Name
C. difficile toxin A+B tcdA+tcdB genes NAA+probe Ql (Stl)
Consumer Name Alpha
Clostridioides difficile toxin A+B tcdA+tcdB genes, Stool

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.56
Last Updated
Version 2.73
Change Reason
Removed parentheses around the gene names in the Component based on the current LOINC model; Updated genus name from Clostridium to Clostridioides based on current (2019) accepted nomenclature for this genus [PMID:27370902].
Order vs. Observation
Common US Lab Results Rank

Member of these Panels

LOINC Long Common Name
95183-0 Clostridioides difficile toxin and BI-NAP1-027 strain DNA panel - Stool by NAA with probe detection
79381-0 Gastrointestinal pathogens panel - Stool by NAA with probe detection

Language Variants Get Info

zh-CNChinese (China)
艰难梭菌毒素 A+B tcdA+tcdB 基因:存在情况或阈值:时间点:大便:序数型:探针法.基因扩增.靶向
nl-NLDutch (Netherlands)
Clostridioides difficile toxine A+B (tcdA+tcdB) genen:aanwezigheid:moment:feces:ordinaal:moleculaire techniek (PCR)
fr-FRFrench (France)
Clostridioides difficime toxines A+B tcdA+tcdB gènes:Présence/Seuil:Ponctuel:Selles:Qualitatif:PCR amplification de cible
de-DEGerman (Germany)
Clostridioides difficile Toxine A+B tcdA+tcdB-Gene:Nachweis oder Schwellenwert:Zeitpunkt:Stuhl:Ordinal:Zielfragmentamplifikation mit Sondendetektion
it-ITItalian (Italy)
Clostridium Difficile (tcdA+tcdB), geni tossine A+B:PrThr:Pt:Feci:Ord:Sonda.amp.tar
es-MXSpanish (Mexico)
Toxina de Clostridioides difficile A + B genes tcdA + tcdB:Presencia o umbral:Punto temporal:Heces:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
es-ESSpanish (Spain)
Gen de la toxina del Clostridium difficile A+B (tcdA+tcdB):PrThr:Punto temporal:Heces:Ord:Sonda con amplificación dirigida

LOINC FHIR® API Example - CodeSystem Request Get Info