81328-7Cytomegalovirus [Presence] in Lower respiratory specimen by Shell vial cultureActive
Examples of lower respiratory tract specimens include broncho-alveolar lavage, bronchial wash, tracheal aspirate, sputum, or lung tissue.
Source: Regenstrief LOINC
Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). It contains a linear double-stranded DNA encased in an icosahedral capsid that is surrounded by a viral envelope. It replicates slowly and may take weeks for the infection to become visible microscopically. Its life cycle includes a lytic and a latent phase. During the lytic phase the cytoskeleton of the infected cell is disrupted and becomes very large. The enlarged cell eludes detection by natural killer (NK) cells by encoding UL16. UL16 is a protein that binds to the ligand NDG2D which is a surface receptor on NK cells and, when blocked, prevents the CMV infected cell from apoptotic signaling to NK cells to destroy it.[https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv] In the US one in three children are infected by CMV by the age of five and over half of adults are infected by age 40. Infection with CMV is mostly asymptomatic. Symptoms when present include fever, sore throat, fatigue, swollen glands. CMV can occasionally lead to mononucleosis or hepatitis. Immunocompromised patients experience much more acute symptoms that can affect the eyes, lungs, liver, esophagus, stomach, and intestines. For babies born with CMV, involvement with the brain, spleen, lung, liver can occur. In addition, there may be growth problems and hearing loss which is the most common symptom in congenital CMV infection. CMV is transmitted in urine, saliva, blood, tears, semen and breast milk by direct contact. Normally no treatment is necessary, but for severe cases medication is available.[https://www.cdc.gov/cmv/overview.html] Source: Regenstrief LOINC
LP36602-8 Shell vial culture
Virus culture is often more sensitive than trying to detect viruses directly in clinical samples. Shell vial culture is a modification of the conventional cell culture technique for rapid detection of viruses in vitro. The technique involves inoculation of the clinical specimen on to cell monolayer grown on a cover slip in a shell vial culture tube, followed by low speed centrifugation and incubation. This system works on the principle that the low speed centrifugation enhances viral infectivity to the susceptible cells. It is thought that the minor trauma to the cell surface produced as a result of low speed centrifugation mechanical force enhances the viral entry in to the cells, which in turn reduces the total time taken for the virus to produce infection of cells. Virus may be detected by direct fluorescent antibody (DFA) or indirect fluorescent antibody (IFA) staining within hours or days of inoculation. Source: Regenstrief LOINC
- Shell vial culture
- Short Name
- CMV Lower Resp Ql Shell Vial Cult
- Display Name
- CMV Shell vial culture Ql (Lower resp)
- First Released
- Version 2.56
- Last Updated
- Version 2.56
- Order vs. Observation
Example Answer List LL360-9
Source: Regenstrief Institute
|Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
Member of these Groups
Language Variants Get Info
- zh-CNChinese (CHINA)
存在情况或阈值: 时间点: 呼吸道.下: 序数型: 细胞培养瓶培养法
- fr-CAFrench (CANADA)
Présence-Seuil: Temps ponctuel: Système respiratoire.inférieur: Ordinal: Culture sur lame en flacon
- fr-FRFrench (FRANCE)
Présence/Seuil: Ponctuel: Voies respiratoires inférieures: Qualitatif: Culture fiole de coquille
- it-ITItalian (ITALY)
PrThr: Pt: Sistema respiratorio.inferiore: Ord: Shell vial, coltura
- es-ESSpanish (SPAIN)
PrThr: Punto temporal: Tracto respiratorio inferior: Ord: Cultivos en "shell vial"
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Copyright © 2019 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright