LOINC
Version 2.67

81715-5Deprecated Centromere protein B Ab [Presence] in Cerebral spinal fluid by ImmunoblotDeprecated

Status Information

Status
Deprecated
Reason
Duplicate
Comment
Created with Method "IB" but upon further review found to be "IA", which makes this term a duplicate.
Map-To Long Common Name Mapping Guidance
63533-4 Centromere protein B Ab [Presence] in Cerebral spinal fluid by Immunoassay

Part Description

LP71684-2   Centromere protein B Ab
Major centromere autoantigen B, also known as centromere protein B or CENP-B, is encoded by the CENPB gene located on chromosome 20p13. CENP-B interacts with chromosomal centromeric heterochromatin and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. [UniProt: P07199] CENP-B plays a direct role in stablizing CENP-C, which is a kinetochore assembly nucleator, and recruiting CENP-A, which marks and maintains centromere position. Chromosomes that have centromeres without bound CENP-B, including the human Y chromosome, are more likely to missegregate at much higher rates than chromosomes with CENP-B containing centromeres. [PMID: 25942623] Autoantibodies to both CENP-A and CENP-B are markers for scleroderma and other rheumatic diseases. [PMID: 17210244] Source: Regenstrief LOINC, UniProt: P07199

Fully-Specified Name

Component
Centromere protein B Ab
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
IB

Additional Names

Short Name
Deprecated Centromere B Ab CSF Ql IB
Display Name
Centromere protein B Ab IB Ql (CSF)

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.58
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Member of these Groups

LG29561-4 Centromere protein B Ab|PrThr|Pt|CSF

Language Variants Get Info

zh-CNChinese (CHINA)
着丝点蛋白 B 抗体:存在情况或阈值:时间点:脑脊液:序数型:免疫印迹法
nl-NLDutch (NETHERLANDS)
centromeereiwit B As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:immunoblotting
et-EEEstonian (ESTONIA)
Tsentromeer B vastased antikehad:PrThr:Pt:CSF:Ord:IB
fr-BEFrench (BELGIUM)
Centromère. Protéine B Ac:PrThr:Temps ponctuel:LCR:Ordinal:Immunoblot
fr-CAFrench (CANADA)
Centromère protéine B , Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Immunoblot
it-ITItalian (ITALY)
Centromero, proteina B , Ab:PrThr:Pt:LCS:Ord:IB
ru-RURussian (RUSSIAN FEDERATION)
Центромерный протеин B Ат:PrThr:ТчкВрм:ЦСЖ:Пор:ИБ
es-ESSpanish (SPAIN)
Proteína B del centrómero Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Inmunoblot (IB)
tr-TRTurkish (TURKEY)
Sentromer protein B Ab:MevcEşik:Zmlı:BOS:Srl:IB

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81715-5