LOINC
Version 2.67

81717-1Deprecated Ganglioside GM1 IgG Ab [Presence] in Cerebral spinal fluid by ImmunoblotDeprecated

Status Information

Status
Deprecated
Reason
Duplicate
Comment
Created with Method "IB" but upon further review found to be "IA", which makes this term a duplicate.
Map-To Long Common Name Mapping Guidance
63242-2 Ganglioside GM1 IgG Ab [Presence] in Cerebral spinal fluid by Immunoassay

Part Descriptions

LP36423-9   Ganglioside GM1
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc–GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. [PMID: 21214559] Source: Regenstrief LOINC, PMID: 2121455

LP222219-0   Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC, PMID: 2121455

Fully-Specified Name

Component
Ganglioside GM1 Ab.IgG
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
IB

Additional Names

Short Name
Deprecated GM1 Gangl IgG CSF Ql IB
Display Name
Ganglioside GM1 IgG IB Ql (CSF)

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.58
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Member of these Groups

LG26349-7 Ganglioside GM1 Ab.IgG|PrThr|Pt|CSF

Language Variants Get Info

zh-CNChinese (CHINA)
神经节苷脂 GM1 抗体.IgG:存在情况或阈值:时间点:脑脊液:序数型:免疫印迹法
nl-NLDutch (NETHERLANDS)
ganglioside GM1 As.IgG:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:immunoblotting
et-EEEstonian (ESTONIA)
Gangliosiid GM1 antikehad.IgG:PrThr:Pt:CSF:Ord:IB
fr-BEFrench (BELGIUM)
Ganglioside GM1 Anticorps. IgG:PrThr:Temps ponctuel:LCR:Ordinal:Immunoblot
fr-CAFrench (CANADA)
Ganglioside GM1 , IgG:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Immunoblot
it-ITItalian (ITALY)
Ganglioside GM1 , Ab.IgG:PrThr:Pt:LCS:Ord:IB
ru-RURussian (RUSSIAN FEDERATION)
Ганглиозид GM1 Ат.IgG:PrThr:ТчкВрм:ЦСЖ:Пор:ИБ
es-ESSpanish (SPAIN)
Gangliósido GM1 IgG:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Inmunoblot (IB)
tr-TRTurkish (TURKEY)
Gangliozid GM1 Ab.IgG:MevcEşik:Zmlı:BOS:Srl:IB

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81717-1