LOINC
Version 2.72

82188-4Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with non-probe detectionActive

Term Description

This assay detects the presence of nucleic acid sequences from the Varicella zoster virus DNA in cerebrospinal fluid (CSF) using PCR and non-probe based detection methods, such as melt curve analysis. This term was created for, but is not limited in use to, BioFire's FilmArray Meningitis/Encephalitis Panel, which is intended for the detection and identification of nucleic acids from multiple bacteria, viruses, and yeast directly from CSF obtained via lumbar puncture from individuals with signs and/or symptoms of meningitis and/or encephalitis.
Source: Regenstrief LOINC

Part Description

LP14853-3   Varicella zoster virus
Varicella zoster virus (VZV) is a double-stranded alphaherpesvirus that causes seasonal outbreaks of chickenpox and shingles in non-immunized populations. VZV is highly infectious and is transmitted by contact with the ruptured fluid filled blisters and respiratory secretions of infected individuals. Immunity post infection is usually lifelong though the latent virus inhabits the sensory nerve ganglia where it can reactivate causing shingles when immunity declines with aging.[http://jvi.asm.org/content/88/24/13936.full] In the over fifty strains of VZV that have been sequenced it has been found that a single nucleotide polymorphism occurs about every 100 bases. The patterns of polymorphisms in VZV correlate with different geographical regions of infection and is the basis for the classification of viral clades.[https://grose.lab.uiowa.edu/vzv-genomes-and-evolution] Breuer proposed the nomenclature for the VZV clades as 1-5 with the suspected clades VI and VII to be confirmed later. The geographical regions associated with the seven clades are as follows:
Clades 1 and 3-represent the dominant clades of the circulating VZV in Europe and the Americas
Clades 4 and 5-found in Africa
Clade VI found in France, Italy
Clade VII exclusively isolated in the US
Clade 2-Asia from Korea, Japan, China not found in India, Nepal and Bangladesh where clades 4 and 5 were dominant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054591/ Source: Regenstrief LOINC

Fully-Specified Name

Component
Varicella zoster virus DNA
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
Non-probe.amp.tar

Additional Names

Short Name
VZV DNA CSF Ql NAA+non-probe
Display Name
VZV DNA NAA+non-probe Ql (CSF)
Consumer Name Alpha
Varicella zoster virus (VZV; Chickenpox), Spinal fluid

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.63
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
82180-1 Meningitis+Encephalitis pathogens panel - Cerebral spinal fluid by NAA with non-probe detection

Member of these Groups

LG32750-8 Varicella zoster virus

Language Variants Get Info

zh-CNChinese (China)
水痘带状疱疹病毒 DNA:存在情况或阈值:时间点:脑脊液:序数型:非探针法.基因扩增.靶向
fr-CAFrench (Canada)
Virus varicelle-zona , ADN:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Non-sonde.amplification de cible
fr-FRFrench (France)
Varicelle zona virus ADN:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Non-PCR amplification de cible
it-ITItalian (Italy)
Varicella zoster, virus DNA:PrThr:Pt:LCS:Ord:Non-sonda.amp.tar
es-MXSpanish (Mexico)
ADN del virus de la varicela zóster:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Amplificación de ácidos nucleicos con detección sin sonda
es-ESSpanish (Spain)
Virus Varicella zoster ADN:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Amplificación del objetivo no basado en sonda

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82188-4