82395-5Ganglioside GD1a IgG Ab [Presence] in Serum by Line blotActive
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC
LP14393-0 Ganglioside GD1a
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. [PMID:21214559] Source: Regenstrief LOINC, PMID: 2121455
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC
- Ganglioside GD1a Ab.IgG
- Line blot
- Short Name
- GD1a Gangl IgG Ser Ql Line blot
- Display Name
- Ganglioside GD1a IgG Line blot Ql (S)
- Consumer Name Alpha
- Ganglioside GD1a IgG antibody, Blood
Example Answer List LL360-9
Source: Regenstrief Institute
|Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
- First Released
- Version 2.58
- Last Updated
- Version 2.66
- Change Reason
- This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
- Order vs. Observation
Member of these Panels
|LOINC||Long Common Name|
|82455-7||Ganglioside Ab panel - Serum|
Member of these Groups
|LG23931-5||Ganglioside GD1a Ab.IgG|
Language Variants Get Info
- zh-CNChinese (China)
- 神经节苷脂 GD1a 抗体.IgG:
存在情况或阈值: 时间点: 血清: 序数型: 线点印迹法
- nl-NLDutch (Netherlands)
- ganglioside GD1a As.IgG:
aanwezigheid: moment: serum: ordinaal: lijnblot
- fr-CAFrench (Canada)
- Ganglioside GD1a , IgG:
Présence-Seuil: Temps ponctuel: Sérum: Ordinal: Immunoessai sur bandelette
- fr-FRFrench (France)
- Ganglioside GD1a anticorps IgG:
Présence/Seuil: Ponctuel: Sérum: Qualitatif: Blot en ligne
- it-ITItalian (Italy)
- Ganglioside GD1a Ab.IgG:
PrThr: Pt: Siero: Ord: Line blot
- es-MXSpanish (Mexico)
- Gangliósido GD1a Ab.IgG:
Presencia o umbral: Punto temporal: Suero: Ordinal: Mancha de línea
- es-ESSpanish (Spain)
- Gangliosido GD1a IgG:
PrThr: Punto temporal: Suero: Ord: Line blot
LOINC FHIR® API Example - CodeSystem Request Get Info
Third Party Copyright
This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.
This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.
Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or email@example.com<mailto:firstname.lastname@example.org>. This may incur a fee in SNOMED International non-Member countries.
Copyright © 2022 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright