LOINC
Version 2.67

82420-1Deprecated Jo-1 extractable nuclear Ab [Presence] in Cerebral spinal fluid by ImmunoblotDeprecated

Status Information

Status
Deprecated
Reason
Duplicate
Comment
Created with Method "IB" but upon further review found to be "IA", which makes this term a duplicate.
Map-To Long Common Name Mapping Guidance
63267-9 Jo-1 extractable nuclear Ab [Presence] in Cerebral spinal fluid by Immunoassay

Part Description

LP16719-4   Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. [PMID: 23573256] Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. [PMID: 17392287] Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Fully-Specified Name

Component
Jo-1 extractable nuclear Ab
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
IB

Additional Names

Short Name
Deprecated ENA Jo1 Ab CSF Ql IB
Display Name
Jo-1 extractable nuclear Ab IB Ql (CSF)

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Member of these Groups

LG20855-9 Jo-1 extractable nuclear Ab|PrThr|Pt|CSF

Language Variants Get Info

zh-CNChinese (CHINA)
Jo-1 可提取性核 抗体:存在情况或阈值:时间点:脑脊液:序数型:免疫印迹法
nl-NLDutch (NETHERLANDS)
jo-1 extraheerbaar nucleair As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:immunoblotting
fr-BEFrench (BELGIUM)
Jo-1 nucléaire soluble Ac:PrThr:Temps ponctuel:LCR:Ordinal:Immunoblot
fr-CAFrench (CANADA)
Jo-1 nucléaire soluble , Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Immunoblot
it-ITItalian (ITALY)
Jo-1, nucleare estraibile , Ab:PrThr:Pt:LCS:Ord:IB
ru-RURussian (RUSSIAN FEDERATION)
Jo-1 экстрагируемый ядерный Ат:PrThr:ТчкВрм:ЦСЖ:Пор:ИБ
es-ESSpanish (SPAIN)
Jo-1 Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Inmunoblot (IB)
tr-TRTurkish (TURKEY)
Jo-1 öztlenebilir çekirdek Ab:MevcEşik:Zmlı:BOS:Srl:IB

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82420-1