82448-2TIF1-gamma Ab [Presence] in Serum by Line blotActive
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC
Transcriptional intermediary factor 1-gamma (TIF1-gamma or E3 ubiquitin-protein ligase TRIM33), induces inactivation of the SMAD4 protein, which promotes cell growth (including malignant tumours) by inhibiting the anti-proliferative effects of TGF-beta. Anti-TIF1-gamma autoantibodies have been associated with adult- and juvenile-onset dermatomyositis (DM), and particularly with cancer-associated DM. [PMID: 20501546] Source: Regenstrief LOINC, PMID: 20501546
- TIF1-gamma Ab
- Line blot
- Short Name
- TIF1-gamma Ab Ser Ql Line blot
- Display Name
- TIF1-gamma Ab Line blot Ql (S)
- First Released
- Version 2.58
- Last Updated
- Version 2.66
- Change Reason
- This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
- Order vs. Observation
Example Answer List LL360-9
Source: Regenstrief Institute
|Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
Language Variants Get Info
- zh-CNChinese (CHINA)
- TIF1-gamma 抗体:
存在情况或阈值: 时间点: 血清: 序数型: 线点印迹法
- nl-NLDutch (NETHERLANDS)
- TIF1-gamma As:
aanwezigheid: moment: serum: ordinaal: lijnblot
- fr-FRFrench (FRANCE)
- TIF1 gamma anticorps:
Présence/Seuil: Ponctuel: Sérum: Qualitatif: Blot en ligne
- es-ESSpanish (SPAIN)
- TIF1-gamma Anticuerpos:
PrThr: Punto temporal: Suero: Ord: Line blot
LOINC FHIR® API Example - CodeSystem Request Get Info
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Copyright © 2019 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright