LOINC
Version 2.67

82449-0Titin Ab [Presence] in Serum by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Description

LP220407-3   Titin
The titin protein plays a role in the assembly and functioning of striated muscles by connecting individual microfilaments, and may play a role in chromosome condensation and segregation during mitosis in non-muscle cells. [UniProt: Q8WZ42] Myasthenia gravis (MG) is an autoimmune disease mediated by antibodies against the acetylcholine receptor (AChR) in the postsynaptic membrane of the motor end plate, but antibodies against other targets, including titin, also play an important role. Anti-titin autoantibodies are also a sensitive marker for thymoma, which is often associated with MG, especially in patients with MG who are younger than 60 years old. [PMID: 11405802] Source: Regenstrief LOINC, PMID: 11405802

Fully-Specified Name

Component
Titin Ab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
Line blot

Additional Names

Short Name
Titin Ab Ser Ql Line blot
Display Name
Titin Ab Line blot Ql (S)

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
肌巨蛋白 抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法
fr-FRFrench (FRANCE)
Titine anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
es-ESSpanish (SPAIN)
Titina Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82449-0