Version 2.73

82660-2Glutamate decarboxylase Ab [Presence] in Serum or Plasma by ImmunofluorescenceActive

Term Description

This assay detects both the 65kD and 67kD isoforms of glutamate decarboxylase but does not distinguish between the two.
Source: Regenstrief LOINC

Part Description

LP230194-5   Glutamate decarboxylase
Paraneoplastic neurological syndrome (PNS) is an autoimmune disorder that is manifested by progressive central, peripheral and/or autonomic nervous system symptoms. The neurological symptoms include encephalitis, autonomic failure, peripheral neuropathy, cerebellar ataxia, visual complaints and more. The antibodies that attack the neural tissue develop in response to tumor cells. The neoplasm may or may not be detectable using conventional imaging modalities. Since PNS can be associated with multiple antibodies testing usually includes a panel of PNS antibodies. In addition, the different PNS antibodies are associated with certain cancers so the antibody pattern can assist in identifying the specific tumor if it was previously undiagnosed. [PMID:22412264]Glutamate decarboxylase (GAD) is an enzyme that leads to the creation of the major neurotransmitter gamma-aminobutyrate (GABA). The initial discovery of GAD antibodies was found in a patient with stiff-person syndrome. Later, GAD antibodies were identified in many patients with type 1 diabetes. Patients with chronic cerebellar ataxia, drug-resistant epilepsy and myoclonus have also been found to have GAD antibodies.[PMID:12536283] GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. GAD65 antibodies are specific to patients with insulin-dependent diabetes.[PMID:7532143] GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years.[PMID:11114103] Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Regenstrief LOINC, Glutamate (Wikipedia)

Fully-Specified Name

Glutamate decarboxylase Ab

Additional Names

Short Name
GAD Ab SerPl Ql IF
Display Name
Glutamate decarboxylase Ab IF Ql
Consumer Name Alpha
Glutamate decarboxylase antibody, Blood

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.58
Last Updated
Version 2.58
Order vs. Observation

Language Variants Get Info

zh-CNChinese (China)
谷氨酸脱羧酶 抗体:存在情况或阈值:时间点:血清/血浆:序数型:免疫荧光法
nl-NLDutch (Netherlands)
glutamaatdecarboxylase As:aanwezigheid:moment:serum of plasma:ordinaal:immunofluorescentie
fr-FRFrench (France)
Glutamate décarboxylase anticorps:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Immunofluorescence
it-ITItalian (Italy)
Glutammato decarbossilasi Ab:PrThr:Pt:Siero/Plasma:Ord:IF
es-MXSpanish (Mexico)
Glutamato descarboxilasa Ab:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Inmunofluorescencia (IF)
es-ESSpanish (Spain)
Glutamato descarboxilasa Anticuerpos:PrThr:Punto temporal:Suero o Plasma:Ord:Inmunofluorescencia (IF)

LOINC FHIR® API Example - CodeSystem Request Get Info