Version 2.72

82894-7Pregnanediol/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol [Molar ratio] in UrineActive

Term Description

The quantitative ratios of various steroids in urine are measured to diagnose conditions such as 17-alpha-, 21-, and 11-beta hydroxylase deficiencies, pseudohypoaldosteronismus, 3-beta hydroxysteroid dehydrogenase deficiency, corticosterone methyl oxidase deficiency, 11-beta hydroxysteroid dehydrogenase types 1 and 2 deficiency, and 5-alpha reductase deficiency. The results along with clinical symptoms and past medical history are used for the assessment and treatment of the associated deficiency or condition. Below are examples of various disorders and their associated urinary findings:
1. 17-alpha hydroxylase deficiency: (THA+THB+5aTHB)/(THE+THF+5aTHF) > 10, (THA+THB+5aTHB)/(AN+ET) > 10.
2. 21-hydroxylase deficiency: 17HP/(THE+THF+5aTHF) > 0.25, PT/(THE+THF+5aTHF) > 0.25.
3. 11-beta HSD2 deficiency: (THF+5aTHF)/THE > 3
4. 11-beta HSD1 deficiency: (THF+5aTHF)/THE < 0.1
5. 11-beta hydroxylase deficiency: 100*THS/(THE+THF+5aTHF) > 10, 100*THDOC/(THE+THF+5aTHF) > 10
6. Pseudohypoaldosteronismus: 100*THALDO/(THE+THF+5aTHF) > 5
7. 5-alpha reductase: ET/AN > 5, THF/5aTHF > 10
Where AN = Androsterone, ET= etiocholanolone, 17HP= metabolites of 17-OH-progesterone (pregnandiol, pregnantriol, 17-OH-pregnanolone), THA = tetrahydro compound A, THB = tetrahydrocorticosterone, 5aTHB =5 alpha tetrahydrocorticosterone, THE = tetrahydrocortisone, THF = Tetrahydrocortisone, 5aTHF = 5a-tetrahydrocortisone or Allo-tetrahydrocortisone, THS = tetrahydrodeoxycortisol, THALDO = tetrahydroaldosterone, and THDOC =tetrahydrodeoxycortisone
[NLM Catalog ID:101631718]
Source: Regenstrief LOINC

Part Descriptions

LP15815-1   Pregnanediol
An inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol has two hydroxyl groups, at 3-alpha and 20-alpha. It is detectable in URINE after OVULATION and is found in great quantities in the pregnancy urine. Source: National Library of Medicine, MeSH 2006

LP15815-1   Pregnanediol
Allo-pregnanediol (5α-pregnane-3α,20α-diol), pregnanolone (5β-pregnane-3α-ol-20-one), epipregnanolone (3β-hydoxy-5β-pregnan-20-one) and pregnanediol (5ß-pregnane-3α,20α-diol) are metabolites of progesterone. During pregnancy and in certain phases of the menstruation cycle, these metabolites are excreted at higher levels. They are also important markers in steroid profile analysis in urine for the evaluation of an adrenal 21-hydroxylase-deficiency. Source: Regenstrief LOINC

Fully-Specified Name

Pregnanediol/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol

Additional Names

Short Name
Pregnanediol/THE+THF+5a-THF Ur-sRto
Display Name
Pregnanediol/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol (U) [Molar ratio]
Consumer Name Alpha
Pregnanediol/Tetrahydrocortisone+tetrahydrocortisol+5-alpha Tetrahydrocortisol, Urine

Basic Attributes

First Released
Version 2.58
Last Updated
Version 2.58
Order vs. Observation

Member of these Panels

LOINC Long Common Name
73886-4 Steroid fractions panel - Urine

Member of these Groups

LG37445-0 Pregnanediol/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol|SRto|Urine

Language Variants Get Info

zh-CNChinese (China)
孕二醇/四氢可的松+四氢皮质醇+5-alpha 四氢皮质醇:物质的量比率:时间点:尿液:定量型:
nl-NLDutch (Netherlands)
pregnaandiol/tetrahydrocortison + tetrahydrocortisol + 5-alfa tetrahydrocortisol:molaire verhouding:moment:urine:kwantitatief:
fr-FRFrench (France)
Prégnanediol/tétrahydrocortisone+tétrahydrocortisol+5-alpha-tétrahydrocortisol:Moles ratio:Ponctuel:Urine:Numérique:
it-ITItalian (Italy)
Pregnandiolo/Tetraidrocortisone+tetraidrocortisolo+5-alfa tetraidrocortisolo:Srto:Pt:Urine:Qn:
es-MXSpanish (Mexico)
Pregnanediol / tetrahidrocortisona + tetrahidrocortisol + 5-alfa tetrahidrocortisol:Proporción de sustancia:Punto temporal:Orina:Cuantitativo:
es-ESSpanish (Spain)
Pregnandiol/Tetrahidrocortisona+tetrahidrocortisol+5-alfa-tetrahidrocortisol:Relacion de Sustancia:Punto temporal:Orina:Qn:

Example Units

Unit Source
{ratio} Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info