Version 2.72

82897-0Pregnanediolone/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol [Molar ratio] in 24 hour UrineActive

Term Description

The quantitative ratios of various steroids in urine are measured to diagnose conditions such as 17-alpha-, 21-, and 11-beta hydroxylase deficiencies, pseudohypoaldosteronismus, 3-beta hydroxysteroid dehydrogenase deficiency, corticosterone methyl oxidase deficiency, 11-beta hydroxysteroid dehydrogenase types 1 and 2 deficiency, and 5-alpha reductase deficiency. The results along with clinical symptoms and past medical history are used for the assessment and treatment of the associated deficiency or condition. Below are examples of various disorders and their associated urinary findings:
1. 17-alpha hydroxylase deficiency: (THA+THB+5aTHB)/(THE+THF+5aTHF) > 10, (THA+THB+5aTHB)/(AN+ET) > 10.
2. 21-hydroxylase deficiency: 17HP/(THE+THF+5aTHF) > 0.25, PT/(THE+THF+5aTHF) > 0.25.
3. 11-beta HSD2 deficiency: (THF+5aTHF)/THE > 3
4. 11-beta HSD1 deficiency: (THF+5aTHF)/THE < 0.1
5. 11-beta hydroxylase deficiency: 100*THS/(THE+THF+5aTHF) > 10, 100*THDOC/(THE+THF+5aTHF) > 10
6. Pseudohypoaldosteronismus: 100*THALDO/(THE+THF+5aTHF) > 5
7. 5-alpha reductase: ET/AN > 5, THF/5aTHF > 10
Where AN = Androsterone, ET= etiocholanolone, 17HP= metabolites of 17-OH-progesterone (pregnandiol, pregnantriol, 17-OH-pregnanolone), THA = tetrahydro compound A, THB = tetrahydrocorticosterone, 5aTHB =5 alpha tetrahydrocorticosterone, THE = tetrahydrocortisone, THF = Tetrahydrocortisone, 5aTHF = 5a-tetrahydrocortisone or Allo-tetrahydrocortisone, THS = tetrahydrodeoxycortisol, THALDO = tetrahydroaldosterone, and THDOC =tetrahydrodeoxycortisone
[NLM Catalog ID:101631718]
Source: Regenstrief LOINC

Part Description

LP188448-7   Pregnanediolone
Pregnanediolone (PDL) is, among other steroids like pregnanetriol (P3), an important marker in the urinary steroid excretion profile for the occurrence of an adrenal 21-hydroxylase-deficiency. Its concentration is also an indication for the effectiveness of medication (e.g., cortisol supplementation) against this disease.[PMID:10399855] Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Regenstrief LOINC, 5-Alpha tetrahydrocortisol

Fully-Specified Name

Pregnanediolone/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol

Additional Names

Short Name
PDL/THE+THF+5a-THF 24h Ur-sRto
Display Name
Pregnanediolone/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol (24H U) [Molar ratio]
Consumer Name Alpha
Pregnanediolone/Tetrahydrocortisone+tetrahydrocortisol+5-alpha Tetrahydrocortisol, Urine

Basic Attributes

First Released
Version 2.58
Last Updated
Version 2.58
Order vs. Observation

Member of these Panels

LOINC Long Common Name
73885-6 Steroid fractions panel - 24 hour Urine

Member of these Groups

LG37446-8 Pregnanediolone/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol|SRto|Urine

Language Variants Get Info

zh-CNChinese (China)
孕烷二醇酮/四氢可的松+四氢皮质醇+5-alpha 四氢皮质醇:物质的量比率:24小时:尿液:定量型:
nl-NLDutch (Netherlands)
pregnaandiolon/tetrahydrocortison + tetrahydrocortisol + 5-alfa tetrahydrocortisol:molaire verhouding:24 uur:urine:kwantitatief:
fr-FRFrench (France)
Prégnanediolone/tétrahydrocortisone+tétrahydrocortisol+5-alpha-tétrahydrocortisol:Moles ratio:24H:Urine:Numérique:
it-ITItalian (Italy)
Pregnanediolone/Tetraidrocortisone+tetraidrocortisolo+5-alfa tetraidrocortisolo:Srto:24h:Urine:Qn:
es-MXSpanish (Mexico)
Pregnanediolona / Tetrahidrocortisona + tetrahidrocortisol + 5-alfa tetrahidrocortisol:Proporción de sustancia:24H:Orina:Cuantitativo:
es-ESSpanish (Spain)
Pregnanelodiona/Tetrahidrocortisona+tetrahidrocortisol+5-alfa-tetrahidrocortisol:Relacion de Sustancia:24 horas:Orina:Qn:

Example Units

Unit Source
{ratio} Example UCUM Units

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